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333 items found for "chronic kidney disease"
Posts (201)
- Chronic itch: emerging treatments following new research concepts
Until recently, itch pathophysiology was poorly understood and treatments were poorly effective in relieving itch. Current progress in our knowledge of the itch processing, the numerous mediators and receptors involved has led to a large variety of possible therapeutic pathways. Currently, inhibitors of IL-31, IL-4/13, NK1 receptors, opioids and cannabinoids, JAK, PDE4 or TRP are the main compounds involved in clinical trials. However, many new targets, such as Mas-related GPCRs and unexpected new pathways need to be also explored. Read full article
- Adenosine receptor signalling in Alzheimer's disease
October 2022 "Alzheimer's disease (AD) is the most common dementia in the elderly and its increasing Despite a better understanding of the disease, the current mainstay of treatment cannot modify pathogenesis suggests adenosine G protein-coupled receptors (GPCRs) are promising therapeutic targets for Alzheimer's disease In this review, we provide an accessible summary of the literature on Alzheimer's disease and the therapeutic
- Adenosine receptor signalling in Alzheimer's disease
August 2022 "Alzheimer's disease (AD) is the most common dementia in the elderly and its increasing prevalence Despite a better understanding of the disease, the current mainstay of treatment cannot modify pathogenesis suggests adenosine G protein-coupled receptors (GPCRs) are promising therapeutic targets for Alzheimer's disease In this review, we provide an accessible summary of the literature on Alzheimer's disease and the therapeutic
Other Pages (132)
- Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney fibroblasts
April 28, 2023 Abstract " Background and purpose: Activated fibroblasts deposit fibrotic matrix in chronic kidney disease (CKD) and G-protein coupled receptors (GPCRs) are the most druggable therapeutic targets Here, we set out to establish a transcriptional profile that identifies activated kidney fibroblasts Correlative histology was performed in human kidney tissue. Tags Adenosine receptor , Fibroblast , Fibrosis , GPCR , Kidney , Tcf21 .
- Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice
While GPR4 deficiency did not show major alterations in disease progression, OGR1 KO mice had higher setting of oxalate-induced nephropathy, the lack of the proton-activated GPCR GPR4 does not influence disease for the pathophysiology of oxalate kidney stones or other crystallopathies." Joller , Carsten A Wagner , Pedro Henrique Imenez Silva Tags G-protein-coupled receptors , acid-base , chronic kidney disease , hyperoxaluria , inflammation , kidney stones Source Contribute to the GPCR News Coming
- Noval insights and therapeutic strategies for tumor-induced kidney pathologies
News < GPCRs in Oncology and Immunology Noval insights and therapeutic strategies for tumor-induced kidney