April 28, 2023 Abstract " Background and purpose: Activated fibroblasts deposit fibrotic matrix in chronic kidney disease (CKD) and G-protein coupled receptors (GPCRs) are the most druggable therapeutic targets Here, we set out to establish a transcriptional profile that identifies activated kidney fibroblasts Correlative histology was performed in human kidney tissue. Tags Adenosine receptor , Fibroblast , Fibrosis , GPCR , Kidney , Tcf21 .

While GPR4 deficiency did not show major alterations in disease progression, OGR1 KO mice had higher setting of oxalate-induced nephropathy, the lack of the proton-activated GPCR GPR4 does not influence disease for the pathophysiology of oxalate kidney stones or other crystallopathies." Joller , Carsten A Wagner , Pedro Henrique Imenez Silva Tags G-protein-coupled receptors , acid-base , chronic kidney disease , hyperoxaluria , inflammation , kidney stones Source Contribute to the GPCR News Coming

News < GPCRs in Oncology and Immunology Noval insights and therapeutic strategies for tumor-induced kidney

Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc and promote disease. how the gut microbiome may be affecting peripheral immune cells, and consequently Western lifestyle diseases Authors Quanbo Wang , Charles R Mackay Tags Gut microbiota , Western lifestyle diseases , portal vein

Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases The consequences of altered neuroimmune activity differ with tissue type and disease and include: skin in targeted treatment approaches to reduce type 2 inflammation and its associated symptoms in these diseases inflammation and its related sensory pathologies in diseases associated with type 2 inflammation." idiopathic urticaria , Chronic obstructive pulmonary disease , Chronic rhinosinusitis with nasal polyps

and Immunology Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases and cancers, including chronic obstructive pulmonary disease (COPD), atherosclerosis, asthma, and pancreatic a new target for diabetes and that CXCR2 antagonists may also attenuate lung injury in coronavirus disease Yishi Xie , Wenbin Kuang , Dawei Wang , Kai Yuan , Peng Yang Tags CXCR2 , CXCR2 antagonist , Cancer , Chronic obstructive pulmonary disease (COPD) , Coronavirus disease 2019 (COVID-19) , Inflammatory disease.

Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health.

deposition of extracellular matrix proteins, particularly collagen, caused by myofibroblasts in response to chronic , increased Gpr176 expression was also observed in other organs affected by fibrosis, including the kidney

In 1983, he joined the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the

October 23-25 Download PDF Program HERE < Back to Full Agenda Student Flash Presentations Health and Disease Cognitive sciences from the University of South Florida, where he researched early-onset Alzheimer’s disease These data demonstrate that Adgrf5 transcript variants are cell-specific in the kidney. Moreover, the complete repertoire of aGPCRs expressed in the kidney is undefined. These results reveal the complete set of aGPCRs expressed in the murine kidney.

Pluznick discovered that olfactory receptors in mice are also expressed in their kidneys and blood vessels This work contributes to a better understanding of how the kidney helps maintain homeostasis in humans

Jurgen Wess’s lab at the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) - NIH,

could promote coronavirus porcine epidemic diarrhea virus (PEDV) infection in African green monkey kidney epithelial cells (Vero) and Lilly Laboratories cell-porcine kidney 1 epithelial cells (LLC-PK1). and more effort is needed to develop economical and efficient vaccines to control or eliminate this disease

Jinqiancao granules are a traditional Chinese medicine used to treat kidney stones and this medicine compounds in Jinqiancao granules and their target mechanisms for the potential treatment of the two diseases networking were utilized to establish a general correlation between Jinqiancao granules and the two diseases Five compounds showed weak antagonistic activity on M3, which was confirmed to be a disease target by experiment-based network reflected a pharmacological relationship between Jinqiancao granules and the two diseases

governs macrophage migration during tissue inflammation Published date December 12, 2023 Abstract "Chronic inflammation is the underlying cause of many diseases, including type 1 diabetes, obesity, and non-alcoholic fatty liver disease. Macrophages are continuously recruited to tissues during chronic inflammation where they exacerbate or

Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia Published date July 1, 2024 Abstract "Imatinib (IM), a breakthrough in chronic myeloid

GPR110 is also highly expressed in the kidney, however, little is known about the function of this receptor To extend our understanding of the role of GPR110 signaling in kidney, we evaluated the urine albumin provide the molecular basis for the renal phenotype, we analyzed in parallel differential expression of kidney

However, the physiological functions of many GPCRs and the involvement of them in autoimmune diseases However, Gpr141 deficiency exacerbated disease conditions of experimental autoimmune encephalomyelitis , an autoimmune disease model for multiple sclerosis, with increased inflammation in the spinal cord. dendritic cells and that targeting GPR141 may be a possible therapeutic intervention for modulating chronic inflammatory diseases."

Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health. he aims to apply this knowledge to develop novel chemical treatments for neuronal and cardiovascular diseases

during prolonged cold exposure Anastasia Georgiadi ADGRF5-mediated regulation of cardiac health and disease Netherlands; 2Department of Experimental Immunology, Amsterdam institute for Immunology and Infectious diseases Georgiadi on the web Endocrine Pharmacology Google Scholar ADGRF5-mediated regulation of cardiac health and disease has evolved to encompass their roles in regulating immune cell response to acute cardiac injury or chronic

the identification of drugs targeting the unique aGPCR receptor family and customize the method for disease-relevant recruited by Vertex Pharmaceuticals (Canada) where he worked on biomarker discovery for inflammatory bowel disease and small molecules drug discovery for polycystic kidney disease. novel pharmacological targets and contribute to the development of innovative treatments for a range of diseases

differentiation, altered mesenchymal cell synthetic function, and reduced lung TGFβ2 deposition, as well as kidney

context-dependent compared to the C5aR1, which has received enormous attention for its role in both acute and chronic inflammatory diseases.

Ductal carcinomas are increasingly diagnosed but identifying which will progress to invasive disease The role of GPR56 in the kidneys has been understudied. A recent study demonstrated that GPR56 in the glomerular endothelial cells promoted diabetic kidney disease physiology, I systematically characterized the function of sodium/hydrogen exchanger 3 in the intestine and kidneys

News < GPCRs in Oncology and Immunology GPCRs and fibroblast heterogeneity in fibroblast-associated diseases About one-third of the commercially available drugs for various diseases target the GPCRs. Understanding the dynamics of GPCR signaling in fibroblasts with disease progression can help in the recognition of the complex interplay of different GPCR subtypes in fibroblast-mediated diseases. Apar K Ganti , Surinder K Batra , Maneesh Jain Tags GPCR signaling , fibroblast behavior , fibrotic diseases

Potential role of GPR109A in macrophages Published date September 2, 2024 Abstract "Inflammatory Bowel Disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract characterized by disrupted immune

ambiguous reports on incidences of GPCR autoantibodies, spurious correlations of autoantibody levels with disease they are correlated poorly or even inversely to haemodynamic, metabolic, and functional markers of disease Tags Chronic non-ischaemic heart failure , Heart failure , Pathophysiology .

There is increasing evidence for an autoimmune aetiology in post-infectious Myalgic Encephalomyelitis/Chronic Anne Krüger , Markus Tölle , Carmen Scheibenbogen Tags GPCR-antibodies , Myalgic Encephalomyelitis/Chronic