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Main objectives: - Learning how to perform advanced GPCR pharmacology data analysis in support of drug discovery and GPCR research, shown with GraphPad Prism - Understanding the pharmacology data analysis framework we use for GPCRs. - Appreciating the practical realities, limitations, and tradeoffs of GPCR data analysis. The participants will increase their ability to perform, understand, and communicate GPCR pharmacology

GPCR Ecosystem.

While GPCRs can exist as monomers, some types, like class C GPCRs, are obligate dimers, either as homodimers The possibility of dimerization in class A and class B GPCRs, however, has been more controversial, despite Class B1 GPCRs are an important subclass of GPCRs that include 15 receptors involved in regulating body Recent studies suggest that class B1 GPCRs can form both homodimers and heterodimers, which may play Examples of class B1 GPCRs forming homodimers include the secretin receptor (SecR)[6] and GLP-1R [7],

G protein-coupled receptors (GPCRs) are among the most promising drug targets. Specifically controlling the activity of GPCR dimers with ligands is a good approach to clarify their This region corresponds to the sodium ion binding site in class A GPCRs that controls the basal state reveal the possibility of developing allosteric compounds able to specifically modulate the activity of GPCR

A G-protein coupled receptors (GPCRs) through a conserved binding site, not present in class B GPCRs For class B GPCRs, previous molecular dynamics (MD) simulation studies have shown PI(4,5)P2 interacting Interestingly, we find that in contrast to class A GPCRs, PI(4,5)P2 appear to stabilize the inactive conformation of GCGR through a binding site conserved across class B GPCRs but absent in class A GPCRs This suggests differences in the regulatory function of PI(4,5)P2 between class A and class B GPCRs."

GPCR Podcast << Back to podcast list Dr. Hannes Schihada About Dr. My project involved the development of FRET/BRET -based GPCR conformational biosensors, which can be Frizzled GPCR s in the lab of Gunnar Schulte at the Karolinska Institute. A GPCRs , GPR3 , GPR6 , and GPR12 . GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand

GPCR Podcast << Back to podcast list Dr. Qing Fan About this episode Dr. Qing is a structural biologist interested in the molecular mechanisms controlling how class C GPCRs transmit GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand

GPCR Podcast << Back to podcast list Dr. Debbie Hay About this episode Dr. Her work is primarily focused on class B GPCRs and their interactions with RAMPs. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand