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Here we demonstrate that GPR84 is highly upregulated in inflamed colon tissues of active ulcerative colitis (UC) patients and dextran sulfate sodium (DSS)-induced colitis mice. macrophages are significantly increased in the colonic mucosa of both the UC patients and the mice with colitis Consistently, GPR84-/- mice are resistant to the development of colitis induced by DSS. CLH536, a novel GPR84 antagonist discovered by us, suppresses colitis by reducing the polarization and

inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition Role of pH-sensing receptors in colitis

Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis

Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis suppresses ISC proliferation, thereby impairing epithelial regeneration and exacerbating DSS-induced colitis with an ADRA2A antagonist, yohimbine, disrupts tyramine-mediated suppression on ISCs and alleviates colitis exacerbation and yielding a targeted therapeutic approach to restore ISC function in colitis." Cao , Rongbin Zhou , Sheng Wang , Xinyang Song , Shu Zhu , Wen Pan Tags Enterococcus , IBD , ISCs , colitis