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Here we demonstrate that GPR84 is highly upregulated in inflamed colon tissues of active ulcerative colitis (UC) patients and dextran sulfate sodium (DSS)-induced colitis mice. macrophages are significantly increased in the colonic mucosa of both the UC patients and the mice with colitis Consistently, GPR84-/- mice are resistant to the development of colitis induced by DSS. CLH536, a novel GPR84 antagonist discovered by us, suppresses colitis by reducing the polarization and

inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition Role of pH-sensing receptors in colitis

Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis

compounds, GLPG1205 progressed into clinical development for the potential treatment of ulcerative colitis

Elucidating novel mechanism of action of spiperone for drug repurposing to prevent and treat murine colitis