Search Results

Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis suppresses ISC proliferation, thereby impairing epithelial regeneration and exacerbating DSS-induced colitis with an ADRA2A antagonist, yohimbine, disrupts tyramine-mediated suppression on ISCs and alleviates colitis exacerbation and yielding a targeted therapeutic approach to restore ISC function in colitis." Cao , Rongbin Zhou , Sheng Wang , Xinyang Song , Shu Zhu , Wen Pan Tags Enterococcus , IBD , ISCs , colitis