< GPCR News < GPCRs in Oncology and Immunology Structural Basis for the Recognition of GPRC5D by Talquetamab Here, we elucidate the structure of GPRC5D complexed with the Fab fragment of talquetamab, using cryo-electron The structure offers insights for optimizing antibody design against GPRC5D for relapsed or refractory Junhyeon Park, Geun Young Mo, Jinwoo Shin, Yunje Cho Tags GPRC5D , Multiple myeloma , class C GPCR , cryo-EM structure , talquetamab Source Contribute to the GPCR News Coming soon Become a Contributor Classified

Committee Sponsors GPCR Retreat Program < Back to schedule Biased agonism at the GLP-1 receptor: from structure Patrick Sexton " Patrick Sexton is a NHMRC Senior Principal Research Fellow and Director, ARC Centre for Cryo-electron Recently, his team has applied cryo-EM to elucidation of the structure and dynamics of GPCRs. Prof.

using cryo-EM. Subsequent work has focused on understanding the molecular basis of GPCR pharmacology through structure In 2016 mini-G proteins were developed as a tool for the structure determination of GPCRs in the fully , and also by electron cryo-microscopy of receptors coupled to mini G protein bound to βγ subunits. to arrestin and also the first structure of a Class D receptor.

Australia Senior Principal Research Fellow, and Director of the Australian Research Council Centre for Cryo-electron More recently, his team has been at the forefront of the application of cryo-EM to elucidate of the structure

mechanism of this family of G protein-coupled receptors using innovative approaches, including biosensors, cryo-EM

13, 2021 at 7:00:00 PM Learn More >> A distinct activation mechanism in GPCR dimers: Insights from cryo-EM John Streicher September 13, 2021 at 9:00:00 PM Learn More >> Through the Looking-Glass: Structure-Based Demet Araç September 17, 2021 at 6:00:00 PM Learn More >> Structure-guided drug discovery Dr. Ross Cheloha September 17, 2021 at 8:00:00 PM Learn More >> Structure and dynamics of GPCRs: lessons from cryo-EM Dr.

Communication of Extracellular Region with Transmembrane Domain in a Holo-Adhesion GPCR Demet Araç Structural Demet Araç on the web Araç Laboratory at UChicago X (Twitter) Structural Insights into the Activation Recently, we have elucidated the high-resolution structures of GPR97 transitioning from its inactive Gregory Tall and our research primarily focuses on the structural and biochemical characterization of microscopy (cryo-EM).

CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Session V Structural mechanisms of AGPCR signaling and function Structural Determinants Of GAIN Domain Autoproteolysis And Cleavage Resistance Of Adhesion G Protein-Coupled Receptors Fabian Pohl Structural studies of the CELSR1 Here, we report the 3.8 Å cryo-EM reconstruction of the CELSR1 ECR which enables unambiguous assignment of the 14 domains within the structure.

Daniel Kahne and Suzanne Walker studying the structure and function of the essential human enzyme, O-GlcNAc Over the course of my graduate work, I gained experience with structural mass spectrometry and protein has made use of several techniques including various mass spectrometry approaches, single particle cryo-EM position after the recording stops. • John will prioritize getting feedback from people outside his lab to structure

Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Atypical Structure

About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Structure-based

The upregulated genes in the adrenal glands (hub genes: Ciart, per2, per3, cry1, and cry2) were enriched GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural

Authors Atsuya Sawabe, Shogo Okazaki, Akira Nakamura, Ryo Goitsuka, Tomonori Kaifu Tags G protein–coupled GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural

Brain’s work there primarily focused on structure prediction of GPCRs from sparse experimental data. of California in San Francisco to continue his training as a postdoctoral researcher where he used structural

His Ph.D. work has been focused on understanding the structure and activation of Class D fungal GPCRs developed novel tools and methodologies to study fungal GPCRs which allowed the determination of the first structures

An expert in GPCR biology, Fiona published the first description of the cloning and structural requirements company, Fiona and her team made considerable breakthroughs in the field of GPCR stabilization and structure-based

The explosion of biomedical data such as in genomics, structural biology, and pharmacology can provide How can we best leverage these exciting new techniques in areas such as protein structure prediction,

Axel Brunger’s lab at Stanford University to study the structure and function of cell-adhesion proteins journey of studying adhesion GPCRs, the challenges he faced, and the progress made in understanding their structure adhesion GPCRs, outlining his collaborations, challenges, and the progress made in understanding their structure collaborations and improved their understanding of the GPCRs through various approaches, including structural the field has seen significant growth, with important discoveries such as the transmembrane region structures

GPCR signal transduction and neuroscience, and she has expanded it in the areas of drug discovery and structural Her research focuses on the structure and function of GTP binding proteins and the molecular mechanisms studying G protein coupled signal transduction for many years and has made key discoveries in G protein structure

Qing is a structural biologist interested in the molecular mechanisms controlling how class C GPCRs transmit

Italy, followed by a Ph.D. in computational medicinal chemistry, during which she developed a taste for structural

Molecular docking was conducted on GPR35-active compounds and GPR35 crystal structure. GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural

She developed expertise over the past two decades studying structure/function relationships of GPCRs

Immunology and Oncology November 17, 2023 Details GPCRs as Therapeutic Modalities September 22, 2023 Details Structural

Kobilka’s lab contributing to the elucidation of high-resolution structures of various GPCRs. Dr.

Presentations Health and Disease, Metabolism, Nervous System, Proteomics and Transcriptomics, Receptor Structure Mihaylov · Anne Bormann Read More 1:00 PM Lunch Read More 2:00 PM Posters Read More 3:00 PM Session V Structural

bioinformatic tool that measures the missense tolerance ratio (MTR) using a three-dimensional (3D) structure GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and Immunology Structural

My primary research focus lies in gaining deeper insights into the structural mechanisms governing G lab for her postdoc in 2018 where she has employed protein engineering, receptor pharmacology, and structural