pathophysiology is not fully understood, but the working hypothesis postulates that a combination of epithelial However, in epithelial cells, OGR1 promotes epithelial to mesenchymal transition (EMT) and inflammation

August 2022 "Epithelial tube formation requires Rho1-dependent actomyosin contractility to generate the We also report on unexpected Fog-independent roles for Smog in maintaining epithelial integrity and organizing wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent manner during epithelial

September 2022 "Epithelial tube formation requires Rho1-dependent actomyosin contractility to generate We also report on unexpected Fog-independent roles for Smog in maintaining epithelial integrity and organizing wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent manner during epithelial

shear stresses display heightened G protein-coupled receptor mechanosignaling and the induction of an epithelial to mesenchymal-like transition through p38α mitogen-activated protein kinase and mucin 15 modulation DiFeo, David Nordsletten Tags G-protein coupled receptors (GPCR) , NF-κB , PLCβ , ascitic currents , epithelial to mesenchymal transition (EMT) , fluid shear stress , glycocalyx , high grade serous ovarian cancer

transition of glioblastoma Published date November 19, 2023 Abstract "G protein-coupled receptor 56 transition, making it a promising therapeutic target (Ganesh et al., 2022). transition in GBM. GPR56 signaling and mesenchymal transition." Authors Raksha A Ganesh , Krishnan Venkataraman , Ravi Sirdeshmukh Tags GPR56 /ADGRG1 , Mesenchymal transition

< GPCR News < GPCRs in Oncology and Immunology Stretch regulates alveologenesis and homeostasis via mesenchymal Mesenchymal cells play key roles in numerous developmental processes. mechanical and chemical signals to activate TGFβ in epithelial cells. To understand the role of mesenchymal Gαq/11 in lung development, we generated constitutive (Pdgfrb-Cre Tamoxifen-induced mesenchymal Gαq/11 gene deletion in adult mice resulted in emphysema associated with