pathophysiology is not fully understood, but the working hypothesis postulates that a combination of epithelial However, in epithelial cells, OGR1 promotes epithelial to mesenchymal transition (EMT) and inflammation

August 2022 "Epithelial tube formation requires Rho1-dependent actomyosin contractility to generate the We also report on unexpected Fog-independent roles for Smog in maintaining epithelial integrity and organizing wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent manner during epithelial

September 2022 "Epithelial tube formation requires Rho1-dependent actomyosin contractility to generate We also report on unexpected Fog-independent roles for Smog in maintaining epithelial integrity and organizing wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent manner during epithelial

promoted liver and kidney fibrosis and pathological angiogenesis, including occurrence of endothelial-to-mesenchymal transition.

Involvement of various chemokine/chemokine receptor axes in trafficking and oriented locomotion of mesenchymal Application of mesenchymal stem cells (MSCs) as an emerging approach was recruited forthe treatment of

distinct signaling and physiological properties: PTH evokes prolonged Gs activation, whereas PTHrP evokes transient

distinct signaling and physiological properties: PTH evokes prolonged Gs activation, whereas PTHrP evokes transient

is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral membrane and regulates epithelial Here, we show that human GPR125 likely undergoes cis-autoproteolysis when expressed in canine kidney epithelial GPR125, an autocleavable adhesion GPCR, appears to play a crucial role in apicobasal polarization in epithelial

, the channel is expressed in various tissues and cell types including neurons as well as glial and epithelial to be discussed and to be put in context as soon as possible to be up-to-date and to accelerate the translation

2022 Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression "P-glycoprotein (P-gp) is a key component of the intestinal epithelium RNA sequencing of intestinal epithelial cells responding to butyrate and secondary bile acids in combination

a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial Here, we examine how HH controls SMO subcellular localization and activity in a polarized epithelium

Here, we discovered that the epithelial-cell-derived antimicrobial peptides defensins activated orphan This study demonstrated the importance of epithelial-neutrophil signaling via the defensin-Mrgpra2 axis

Uterine Corpus Endometrial Carcinoma (UCEC) isa malignanttumorofendometrium epithelial, whichis alsooneofthemostcommonfemalereproductivesystemtumors

receptor 2A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition Role of pH-sensing receptors in colitis GPCRs in Oncology and Immunology Polarizing itch

In vitro, we used IFNα to stimulate human salivary gland epithelial cells (HSGECs), and the results showed signaling is involved in the pathogenesis of pSS and that β-arrestin2 encourages inflammation-induced epithelial

Comparison of the Genomic Activity of an EP4-Receptor and β2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Receptors that Regulate the Release of Superoxide Anions GPR176 promotes fibroblast-to-myofibroblast transition

and process of EBV-induced lymphomagenesis GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma Methods & Updates in GPCR Research Optogenetic Microwell Array Screening

pregnancy, the mammary gland (MG) undergoes remodeling, which involves alveolar differentiation of mammary epithelial

receptors (PAR), a subgroup of GPCRs, form a family of four members (PAR1-4) centrally involved in epithelial toward PAR-expressing tumors but also for treating EGFR/erbB-expressing tumors in cases of resistance to traditional

MDA-MB-231 cells are metastatic when implanted in mice while BT-20 are not and remain epithelial-like

GPCRs in Cardiology, Endocrinology, and Taste SOCS3 inhibits the mesenchymal stromal cell secretory factor

Drugs, and more Selenomethionine Promotes Milk Protein and Fat Synthesis and Proliferation of Mammary Epithelial

analysis uncover GPR183 as a key mediator for methionine to stimulate milk synthesis in mouse mammary epithelial

Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype Mesenchymal

GPCRs in Oncology and Immunology Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq

been a challenge because G protein activation in cells occurs in less than a second, reflecting the transient Using time-resolved cryo-electron microscopy (cryo-EM) and variability analysis to monitor the transitions Twenty transition structures generated from overlapping particle subsets along this pathway provide a The AHD transitioning to a closed conformation prompts the β2–β3 loop to move away from the α5 helix, disrupting an ionic lock and allowing the α5 helix to start transitioning.

deficient mouse models resulted in alterations in the MAM architecture and in the dysregulation of the Ca2+ transient

mediated non-canonical pathway GPCR Screening Reveals that the Metabolite Receptor HCAR3 Regulates Epithelial