shear stresses display heightened G protein-coupled receptor mechanosignaling and the induction of an epithelial to mesenchymal-like transition through p38α mitogen-activated protein kinase and mucin 15 modulation DiFeo, David Nordsletten Tags G-protein coupled receptors (GPCR) , NF-κB , PLCβ , ascitic currents , epithelial to mesenchymal transition (EMT) , fluid shear stress , glycocalyx , high grade serous ovarian cancer

transition of glioblastoma Published date November 19, 2023 Abstract "G protein-coupled receptor 56 transition, making it a promising therapeutic target (Ganesh et al., 2022). transition in GBM. GPR56 signaling and mesenchymal transition." Authors Raksha A Ganesh , Krishnan Venkataraman , Ravi Sirdeshmukh Tags GPR56 /ADGRG1 , Mesenchymal transition

< GPCR News < GPCRs in Oncology and Immunology Stretch regulates alveologenesis and homeostasis via mesenchymal Mesenchymal cells play key roles in numerous developmental processes. mechanical and chemical signals to activate TGFβ in epithelial cells. To understand the role of mesenchymal Gαq/11 in lung development, we generated constitutive (Pdgfrb-Cre Tamoxifen-induced mesenchymal Gαq/11 gene deletion in adult mice resulted in emphysema associated with

tumor formation and growth. (3) GPR37 activates PI3K/Akt/mTOR signal transduction pathways to mediate epithelial-mesenchymal transition (EMT), thereby promoting the progression of NSCLC. Liu , Yingjie Zhu , Huikun Niu , Jing Jie , Shucheng Hua , Xiaoxue Bai , Shuai Wang , Lei Song Tags EMT

Viral Replication by Regulating Ca2+ Flux Published date May 29, 2023 Abstract "Chemokine production by epithelial However, the effect of chemokine on epithelia and how chemokine is involved in coronavirus infection promote coronavirus porcine epidemic diarrhea virus (PEDV) infection in African green monkey kidney epithelial cells (Vero) and Lilly Laboratories cell-porcine kidney 1 epithelial cells (LLC-PK1). This study evaluated the effect of IL-8 on PEDV infection in epithelia.

< GPCR News < GPCRs in Oncology and Immunology GPR176 promotes fibroblast-to-myofibroblast transition Furthermore, fibroblasts abundantly expressed Gpr176 compared to alveolar epithelial cells, endothelial

However, its physiological expression in pediatric embryonal and mesenchymal tumors and its association These findings support wider exploration of PRL3 expression in embryonal and mesenchymal tumors and further

Using an engineered tyrDC-deficient Enterococcus faecalis strain and intestinal epithelial cell-specific knockout mice, we show that Enterococcus-derived tyramine suppresses ISC proliferation, thereby impairing epithelial

Organoid culture was used to assess the stemness and self-renewal capacity of alveolar epithelial type production as well as proinflammatory factor transcription in macrophages and decreased apoptosis in epithelial

Differentiation Published date May 30, 2023 Abstract "Objectives: Dental pulp stem cells (DPSCs) are a type of mesenchymal

Epithelial ovarian cancer (EOC) is a leading cause of death among gynecological malignancies.

protein-coupled receptor , Immune infiltration , Molecular marker , Ovarian cancer , Prognostic model , epithelial

The role of GPR109A was studied in depth and increased expression of this receptor was detected in epithelial Besides, when GPR109A was transiently silenced, the mRNA expression and secretion of IL-1β, IL-6 and

molecular interactions with specific human cell receptors, particularly expressed on human intestinal epithelial cells, immune cells and the nervous system that are shown to hold much promise for clinical translational

Key findings were additionally studied in other breast cancer cell lines and in mammary epithelial cells

science originated from a young age and his desire to gain more knowledge about cancer biology led him to transition Mike then transitioned to pancreatic cancer, questioning why genes are dysregulated in cancer, which He also discussed his experiments and discoveries about GPR161 in mammary epithelial cells, the effect

non-coding RNA (LncRNA) PAXIP1 antisense RNA 1 (PAXIP1-AS1) was found to promote proliferation, migration, EMT

Ross and I chatted about his work and transition to an independent investigator; join me to learn more

Discussion Yamina and John had a detailed discussion about the prospects of staying in academia versus transitioning Academic Position Applications and Transition Preparation John and Yamina discussed the extensive process Yamina questioned whether universities adequately prepare postdocs for the transition to industry or reflected on his career, sharing key moments of realization in his scientific work and his upcoming transition

evaluated by immunohistochemistry (IHC) in 491 cases of NPC and 50 cases of non-cancerous nasopharyngeal epithelium SSTR2 and EGFR was significantly increased in NPC patients compared with non-cancerous nasopharyngeal epithelium

Since then I transitioned into a Scientific Support role to leverage my passion for helping people! By taking a very non-traditional path to obtain a Ph.D. Dr.

Summary Arthur's Career Journey and Transition to Dean Yamina introduced Arthur to her team and discussed Towards the end, they focused on Arthur's transition to become Dean and his decision to move from Australia approach to research and its capacity to translate research into therapeutic commercialization. Arthur's experiences during the Covid-19 pandemic, his journey as a research fellow in Australia, and his transition Translating Discovery Into Clinical Application Arthur and Yamina discussed the importance of translating

Summary Arthur's Career Journey and Transition to Dean Yamina introduced Arthur to her team and discussed Towards the end, they focused on Arthur's transition to become Dean and his decision to move from Australia approach to research and its capacity to translate research into therapeutic commercialization. Arthur's experiences during the Covid-19 pandemic, his journey as a research fellow in Australia, and his transition Translating Discovery Into Clinical Application Arthur and Yamina discussed the importance of translating

regulates cyclin D1 levels through the cAMP/PKA/ERK and PI3K/AKT/GSK3β pathways, and mediates the G1/S transition

populates a high-FRET inactive state, while apo-ACKR3 shows little conformational preference and high transition

innate control of the life cycle of papillomavirus, which are commensal inhabiting the healthy human epithelium

They also discussed the founding of a company focused on GPCRs, the transition from academia to the biotech the differences between academia and the biotech industry, with Aurelien Rizk sharing his experiences transitioning

Next Steps Jacek will collaborate with Alex Romeo on a podcast about transitioning to the industry.