but not fibrosis in a murine model with fibrotic bone Published date May 1, 2024 Abstract "G protein-coupled Fibrous dysplasia (FD) of the bone is characterized by fibrotic, expansile bone lesions caused by activating was hyper-activated in osteoblastic cell lineages using an engineered receptor strategy, developed a fibrotic Zamarioli, Apsara Ram, Gauri Ganesh, Misun Kang, Sunita Ho, Edward C Hsiao Tags Wnt pathway inhibition , fibrotic bone disease , fibrous dysplasia (FD) , osteoblasts , trabecular bone , G-protein coupled receptor signaling

News < GPCRs in Oncology and Immunology GPCRs and fibroblast heterogeneity in fibroblast-associated diseases About one-third of the commercially available drugs for various diseases target the GPCRs. Understanding the dynamics of GPCR signaling in fibroblasts with disease progression can help in the recognition of the complex interplay of different GPCR subtypes in fibroblast-mediated diseases. Sadikot , Apar K Ganti , Surinder K Batra , Maneesh Jain Tags GPCR signaling , fibroblast behavior , fibrotic

fibroblasts Published date April 28, 2023 Abstract " Background and purpose: Activated fibroblasts deposit fibrotic matrix in chronic kidney disease (CKD) and G-protein coupled receptors (GPCRs) are the most druggable

Potential role of GPR109A in macrophages Published date September 2, 2024 Abstract "Inflammatory Bowel Disease of most metabolite-sensing GPCRs analysed, which positively correlated with pro-inflammatory and pro-fibrotic

current research project I use iPSC-derived cardiac fibroblasts to examine cellular signaling in the fibrotic

abundantly expressed Gpr176 compared to alveolar epithelial cells, endothelial cells, and macrophages in the fibrotic

’s research interests lies in the elucidation of signal transduction pathways in cancer, immune and bone second area of interest has been the elucidation of the molecular basis for a rare autosomal human disease The Rottapel lab has shown that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell

However, the physiological functions of many GPCRs and the involvement of them in autoimmune diseases almost no abnormalities in myeloid cell differentiation and compartmentalization in the spleen and bone However, Gpr141 deficiency exacerbated disease conditions of experimental autoimmune encephalomyelitis , an autoimmune disease model for multiple sclerosis, with increased inflammation in the spinal cord. that targeting GPR141 may be a possible therapeutic intervention for modulating chronic inflammatory diseases

inflammation Published date December 12, 2023 Abstract "Chronic inflammation is the underlying cause of many diseases , including type 1 diabetes, obesity, and non-alcoholic fatty liver disease. We detected BLT2 expression in bone marrow derived and peritoneal macrophages of mouse models.

Immunology CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multiple This review highlights the potential as a therapeutic target of the CCR6 receptor in numerous diseases

Retreat Program < Back to schedule Cannabinoid compounds to augment L-DOPA treatment in Parkinson's Disease

Program < Back to schedule Biased agonism at the GLP-1 receptor: from structure to animal models of disease

and Immunology Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases receptor 2 (CXCR2) is G protein-coupled receptor (GPCR) and plays important roles in various inflammatory diseases and cancers, including chronic obstructive pulmonary disease (COPD), atherosclerosis, asthma, and pancreatic a new target for diabetes and that CXCR2 antagonists may also attenuate lung injury in coronavirus disease (COPD) , Coronavirus disease 2019 (COVID-19) , Inflammatory disease.

cellular mechanisms by which mutations in a chloride-proton antiporter cause the renal disorder Dent’s disease Her current research focuses on how metabolic GPCRs cross-talk and interact to regulate appetite and bone

Sponsors GPCR Retreat Program < Back to schedule Genetic Deletion of Atypical VGLUT3 Rescues Huntington’s Disease coupled receptors and their role in neurodegenerative disorders, including Alzheimer's and Huntington's diseases

Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc and promote disease how the gut microbiome may be affecting peripheral immune cells, and consequently Western lifestyle diseases Authors Quanbo Wang , Charles R Mackay Tags Gut microbiota , Western lifestyle diseases , portal vein

Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases The consequences of altered neuroimmune activity differ with tissue type and disease and include: skin neuroimmune interactions that underlie the various sensory and autonomic pathologies in type 2 inflammatory diseases in targeted treatment approaches to reduce type 2 inflammation and its associated symptoms in these diseases CSU , Calcitonin gene-related peptide , Chronic idiopathic urticaria , Chronic obstructive pulmonary disease

and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease GPCR biased signaling to design/develop new pharmacotherapeutics to treat reward- and metabolism-based diseases novel GPCR pharmacotherapies that improve efficacy and minimize side effects for diet-induced metabolic diseases

< GPCR News < GPCRs in Oncology and Immunology Deciphering the genetic landscape of lumpy skin disease through comprehensive genome sequence analysis in India Published date May 23, 2024 Abstract "Lumpy Skin Disease (LSD), a poxvirus disease affecting cattle, emerged in India in 2019 and intensified in 2022, resulting , V Gairola, D Poloju, S Gulzar, K P Singh, R K Singh, G K Sharma Tags Genome sequence , Lumpy skin disease

Bone marrow (BM) samples were collected at baseline for genomic and transcriptomic analysis (n = 32). remission, with or without hematologic count recovery (CR/CRi), and 32% exhibited a ≥50% reduction in bone

reaction networks are an important and emerging tool for the study of cell signaling networks involved in disease One promising potential application of such mathematical models is the study of how disease-causing mutations promote the signaling phenotype that contributes to the disease. and use model-driven explorations to uncover and explore multiple new areas for investigating this disease revealed the potential for previously unknown qualitative differences between seemingly interchangeable disease-promoting

Indian Institute of Science, Bangalore, India, to investigate the mechanisms behind rare mitochondrial diseases at the Cleveland Clinic in Ohio, USA, studying the gut microbiome and its impact on cardiovascular disease gut microbe-derived metabolite called phenylacetylglutamine (PAG), which is linked to cardiovascular disease as targets for more than one-third of all prescribed drugs currently used in the treatment of human diseases

Administration of ITA protects against inflammatory diseases and blockade of ITA production enhances mechanisms, and conjecture a rationale for developing ITA-based therapeutics to treat inflammatory diseases Dan Ye , Pu Wang , Lei-Lei Chen , Kun-Liang Guan , Yue Xiong Tags IRG1/ACOD1 , cancer , inflammatory diseases

Among 41 patients treated at RP2D, a measurable residual disease-negative complete remission (MRD- CR 76%, without differences in MRD- CR rates, OS, or EFS between patients with or without FLT3-mutated disease Benefit was limited to patients with intermediate-risk disease (univariate analysis: P = .01 for OS; improves OS and EFS relative to CLAG-M alone, with benefits primarily in patients with intermediate-risk disease

mechanisms underlying biased agonism at GPCRs and its contribution inflammation and cardiovascular disease His clinical focus is on pulmonary arterial hypertension, a disease of the pulmonary arterioles that causes right heart failure, and he serves as co-director of the Duke Pulmonary Vascular Disease Center

compounds in Jinqiancao granules and their target mechanisms for the potential treatment of the two diseases networking were utilized to establish a general correlation between Jinqiancao granules and the two diseases Five compounds showed weak antagonistic activity on M3, which was confirmed to be a disease target by experiment-based network reflected a pharmacological relationship between Jinqiancao granules and the two diseases

the Receptor Biology Lab, focuses on the development of novel GPCR-based therapeutics that interdict diseases basis of a new technology-based start-up company, HeptOME , to help screen and develop novel longevity/disease-regulating compounds with multidimensional disease efficacy profiles.

the Receptor Biology Lab, focuses on the development of novel GPCR-based therapeutics that interdict diseases basis of a new technology-based start-up company, HeptOME , to help screen and develop novel longevity/disease-regulating compounds with multidimensional disease efficacy profiles.