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7 items found for "fibrous dysplasia (FD)"
- Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone
Fibrous dysplasia (FD) of the bone is characterized by fibrotic, expansile bone lesions caused by activating There are no effective therapies for FD. components of the downstream signaling pathway could serve as a promising therapeutic strategy for FD The Wnt signaling pathway has been implicated in the pathogenesis of FD-like bone, but the specific Wnts bone disease , fibrous dysplasia (FD) , osteoblasts , trabecular bone , G-protein coupled receptor signaling
- GPCRs and fibroblast heterogeneity in fibroblast-associated diseases
Sadikot , Apar K Ganti , Surinder K Batra , Maneesh Jain Tags GPCR signaling , fibroblast behavior , fibrotic
- GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression
abundantly expressed Gpr176 compared to alveolar epithelial cells, endothelial cells, and macrophages in the fibrotic
- Trainee Symposium I
current research project I use iPSC-derived cardiac fibroblasts to examine cellular signaling in the fibrotic
- A disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages
of most metabolite-sensing GPCRs analysed, which positively correlated with pro-inflammatory and pro-fibrotic
- Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney fibroblasts
fibroblasts Published date April 28, 2023 Abstract " Background and purpose: Activated fibroblasts deposit fibrotic
- Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases
mucus production in asthma; loss of sense of smell in chronic rhinosinusitis with nasal polyps; and dysphagia
