proliferation in the progression of experimental pulmonary hypertension in rats Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions GPCRs in Neuroscience Male-specific behavioral

The research of GPCRs in the cochlea is essential for the understanding of the cochlea development, hearing disorders, and the treatment for hearing loss. In addition, hearing loss can be caused by mutations of certain GPCRs, such as Vlgr1, Gpr156, S1P2, and And A1, A2A, and CB2 activation by agonists has protective functions on noise- or drug-induced hearing loss, and hearing protection."

August 2022 "Aims: The pathophysiological mechanism(s) underlying non-alcoholic fatty liver disease (NAFLD) have yet to be fully delineated and only a single drug, peroxisome proliferator-activated receptor (PPAR) α/γ agonist saroglitazar, has been approved. Here, we sought to investigate the role of Regulator of G Protein Signaling 7 (RGS7) in hyperlipidemia-dependent hepatic dysfunction. " Read more at the source #DrGPCR #GPCR #IndustryNews

< GPCR News < GPCRs in Oncology and Immunology Ascitic Shear Stress Activates GPCRs and Downregulates shear stresses are not well understood. upper range of fluid shear stress generated by the accumulation of ascites. We show that ovarian cancer cells exposed to ascitic shear stresses display heightened G protein-coupled These findings along with a shear-induced immunomodulatory secretome position elevated shear stress as

A functional analogue of GBP, stress-responsive peptide (SRP), was also identified in the same species Enhancement of GBP2 expression was observed in both Drosophila larvae and S2 cells under heat stress Authors Masaya Ono , Takashi Matsumura , Eui Jae Sung , Takashi Koyama , Masanori Ochiai , Stephen B Shears

Samples of synovial fluid and peripheral blood were analyzed for CD45+CD3+CD4+GPR15+ and CD45+CD3+CD8 Also, the frequency CD4+/CD8+ GPR15+ T lymphocytes are higher in synovial fluid of established RA patients