< GPCR News < GPCRs in Oncology and Immunology A virally encoded GPCR drives glioblastoma through feed-forward GPCR) US28 encoded by the human cytomegalovirus (HCMV) is associated with accelerated progression of glioblastomas Here, we showed that US28 increased the malignancy of U251 glioblastoma cells by enhancing signaling mediated by sphingosine-1-phosphate (S1P), a bioactive lipid that stimulates oncogenic pathways in glioblastoma Enhanced S1P signaling promoted glioblastoma cell proliferation and survival by activating the kinases

GPCR News < GPCRs in Oncology and Immunology GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment Published date January 31, 2024 Abstract " Background: Glioblastoma Next, A GPI-anchored pH reporter, pHluorin2, was stably expressed in U87 glioblastoma cells to probe Results: We used a pHLourin2 probe to demonstrate how glioblastoma cells acidify their microenvironment We use U87 and U138 glioblastoma cell lines to show how selective induction of ferroptosis occurs in

< GPCR News < GPCRs in Oncology and Immunology Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies Published date October 23, 2023 Abstract Glioblastoma Santoso , Bianca Tobias William , Chih-Yang Wang Tags G-protein-coupled receptor (GPCR) , genome , glioblastoma

synapse formation, maintenance and degeneration Yimin Zou Antibody-drug conjugates targeting CD97 in glioblastoma Yimin Zou on the web UC San Diego Antibody-drug conjugates targeting CD97 in glioblastoma Dimitris Placantonakis Abstract "Glioblastoma (GBM) is the most common and aggressive primary brain malignancy. His laboratory studies oncogenesis in glioblastoma, the most common brain malignancy, and chromatin organization His group has been particularly interested in the role adhesion GPCRs play in glioblastoma biology and

Oncology and Immunology GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma In our earlier study, we reported that GPR56 is expressed heterogeneously in glioblastoma (GBM) and is

compartmentalized Gq signaling by the cytomegalovirus-encoded chemokine US28 receptor in the context of glioblastoma

ADGRA homolog Remoulade in Drosophila Dimitris Placantonakis Antibody-drug conjugates targeting CD97 in glioblastoma

Glioblastoma (GBM) is the most prevalent central nervous system tumor in LFS, with TP53 mutations detected