acute activation of Gs signaling in skeletal muscle (SKM) in vivo and its contribution to whole-body glucose Results: Acute stimulation of GsD signaling in SKM impaired glucose tolerance in lean and obese mice by decreasing glucose uptake selectively into SKM. Clenbuterol injection improved glucose tolerance by increasing insulin secretion in lean mice. UCN2 injection resulted in decreased glucose tolerance associated with lower plasma insulin levels.

Objective: To study the effects of RH on metabolic pathways associated with glucose counterregulation Further, we performed pyruvate and lactate tolerance tests to assess gluconeogenesis. Finally, we conducted epinephrine tolerance test to investigate systemic glycemic excursions to counterregulatory

are thought to calibrate glucagon-like peptide 1 (GLP-1) bioavailability, thereby regulating systemic glucose the gut IEL GLP-1 receptor (GLP-1R) is not required for enteroendocrine L cell GLP-1 secretion and glucose Moreover, independent of glucose control or weight loss, the anti-inflammatory actions of GLP-1RAs require

if this is true for the glucagon receptor (GCGR), which mediates physiological regulation of hepatic glucose

The GLP-1R, a class B1 GPCR, is integral to metabolic regulation, particularly in glucose homeostasis lower insulin release compared to exendin, both ligands exhibit similar efficacy in lowering blood glucose

improved action of the preproglucagon-derived hormones, glucagon, glucagon-like peptide-1 (GLP-1), and glucose-dependent

common extracellular domain of the secretin-like GPCRs family), showed that HRM interacts with the Glucose-dependent

The islets of Langerhans are central to appropriate glucose homeostasis through their secretion of insulin

10μM THC and 10μM CBD reduced mRNA levels of milk proteins (CSN2 and WAP) , lipid synthesizing and glucose

of GHSR1a now extend to regulation of neurogenesis, learning and memory, gastrointestinal motility, glucose

for breast cancer GPCR Activation and Signaling The TAS1R2 G-protein-coupled receptor is an ambient glucose

is exempt from TGFβ-mediated antifibrotic GPCR landscape tampering in lung fibroblasts. βHB inhibits glucose-induced

Antipsychotic displays dual GPCR binding mode GPCRs in Cardiology, Endocrinology, and Taste An extracellular glucose

Caenorhabditis elegans Comparison of infectious complications with BCMA-directed therapies in multiple myeloma Glucose

Receptor (GPCR) Antibodies Treated With Therapeutic Plasma Exchange SUCNR1 regulates insulin secretion and glucose

2021 "3-part randomized, double-blind, placebo-controlled Phase 1 study will evaluate TRV045 safety, tolerability

Favorable safety, tolerability and pharmacokinetic results from the trial warrant further investigation

November 2021 " Chronic use of most opioids causes tolerance; the new compounds avoid this and other

announced positive topline results from its Phase 3 EMERGENT-2 trial evaluating the efficacy, safety, and tolerability

of molecular tools to study GPCR trafficking in real-time opens new avenues for understanding drug tolerance

announced positive top-line data from its Phase 3 KINECT-HD study evaluating the efficacy, safety and tolerability

drugs to evaluated for potential toxicities and side effects, and these key factors must be deemed tolerable

The Phase 1 study will assess the safety, tolerability and pharmacokinetics of CFTX-1554 in healthy subjects

placentation, uteroplacental malperfusion, oxidative stress, endoplasmic reticulum stress, dysregulated immune tolerance

residues critical for β2AR function are under intense selective pressure, while others are more mutation-tolerant

Cannabinoid tolerance in S426A/S430A x beta-arrestin 2 knock-out double mutant mice.

of a human cell surface protein in yeast cells Trevena Reports Favorable TRV045 Topline Safety and Tolerability

Maxion Therapeutics) – BioLeader Interview Tectonic Therapeutic Announces Favorable Phase 1a Safety, Tolerability