Immunology S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia Published date July 1, 2024 Abstract "Imatinib Network pharmacology analysis identified six herbal compounds-ampelopsin, ellagic acid, colchicine, epigallocatechin Morang, Manisha Bisht, Vikas Upadhyay, Surabhi Thapliyal, Shailendra Handu Tags RNA-seq , S1PR , SphK1 , herbal compounds , imatinib resistance , leukemia Source Contribute to the GPCR News Coming soon Become a Contributor

A dynamic mass redistribution technique was applied to evaluate compounds on four GPCRs. Molecular docking was conducted on GPR35-active compounds and GPR35 crystal structure. Results: Seventy compounds were isolated and twelve showed GPCR activity. Seventeen compounds showed NO inhibitory activity. Several compounds showed multi-target properties.

In this study, we explored the capacity of bioactive compounds derived from Gnetum gnemon (GG) for the We retrieved targets for GG-derived compounds and GPCRs-related cancer from databases. We identified a total of 265 targets associated with GG-derived bioactive compounds for the treatment CCND1, and PPARG, which demonstrate as treatment targets for GPCRs-related cancer using GG-derived compounds This study presents a novel approach for comprehending the therapeutic mechanisms of GG-derived active compounds

Subsequently, we selected a compound from a library of backbone cyclic peptides generated toward the PAR PH binding motif, namely the lead compound, Pc(4-4). While the detection of PAR2 may serve as a predictor for ovarian cancer, the novel Pc(4-4) compound may

Specifically, we focus on preclinical evidence of compounds with attractive pharmacological profiles

technology-based start-up company, HeptOME , to help screen and develop novel longevity/disease-regulating compounds

fundamental function of cDC1 by allowing efficient uptake of gut luminal antigens, such as dietary compounds

They discussed strategies for analyzing large compound screening data, emphasizing robust assays and They also discussed the potential of certain drugs, like flumazenil, as 'nails' or compounds that could

different species, we plan to adapt this technology for high-throughput screening of pharmacological compound The platform revealed different mechanisms-of-action of our lead compound when benchmarked against other

research fellow at Monash University, John plays a pivotal role in the pharmacological screening of compounds

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