increase their ability to perform, understand, and communicate GPCR pharmacology data analysis to a high

September 2022 Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid cancer patients for pain management. Although increasing evidence has suggested the direct role of fentanyl on cancer, little is known on the effect of fentanyl on ovarian cancer cells. Methods Proliferation, migration and apoptosis assays were performed in ovarian cancer cells after fentanyl

September 2022 Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Here, we report that the Ovarian Cancer G-Protein Coupled Receptor1 (OGR1 or GPR68) has dual roles in

September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and predicts poor patient outcomes "Triple-negative breast cancer (TNBC) is a particularly aggressive It is generally considered that TNBC is an estrogen-independent breast cancer, while a new estrogen receptor In quantitative comparison, GPER abundance is correlated with the high-risk subtype of TNBC. metastasis, TNM stage III as well as nuclear grade G3 tumors.

Malignancy Published date November 25, 2024 Abstract "The accumulation of ascites in patients with ovarian cancer increases their risk of transcoelomic metastasis. We show that ovarian cancer cells exposed to ascitic shear stresses display heightened G protein-coupled , ascitic currents , epithelial to mesenchymal transition (EMT) , fluid shear stress , glycocalyx , high grade serous ovarian cancer , mechanotransduction , mucin 15 (MUC15) , transcoelomic metastasis Source

Cancer Published date April 18, 2024 Abstract "Ovarian cancer ranks as a leading cause of mortality elevated expression of UCA1 enhances cell proliferation, invasive migration, and therapy resistance in high-grade serous ovarian carcinoma cells, whereas silencing UCA1 reverses these oncogenic phenotypes. cancer. Grade Serous Ovarian Carcinoma , Let-7 miRNAs , Oncogenic Pathways , Ovarian Cancer , Therapy Resistance

FTs, the origin of ovarian cancer, are known to express genes of serous tubal intraepithelial carcinoma (STICs), a precursor lesion of high-grade serous carcinoma (HGSC). PAR2 expression in FTs may serve as an early prediction sensor for ovarian cancer. We show now that knocking down Par2 inhibits ovarian cancer peritoneal dissemination in vivo, pointing serve as a powerful medicament in STICs and ovarian cancer.