Malignancy Published date November 25, 2024 Abstract "The accumulation of ascites in patients with ovarian cancer increases their risk of transcoelomic metastasis. We show that ovarian cancer cells exposed to ascitic shear stresses display heightened G protein-coupled , ascitic currents , epithelial to mesenchymal transition (EMT) , fluid shear stress , glycocalyx , high grade serous ovarian cancer , mechanotransduction , mucin 15 (MUC15) , transcoelomic metastasis Source

Cancer Published date April 18, 2024 Abstract "Ovarian cancer ranks as a leading cause of mortality elevated expression of UCA1 enhances cell proliferation, invasive migration, and therapy resistance in high-grade serous ovarian carcinoma cells, whereas silencing UCA1 reverses these oncogenic phenotypes. cancer. Grade Serous Ovarian Carcinoma , Let-7 miRNAs , Oncogenic Pathways , Ovarian Cancer , Therapy Resistance

FTs, the origin of ovarian cancer, are known to express genes of serous tubal intraepithelial carcinoma (STICs), a precursor lesion of high-grade serous carcinoma (HGSC). PAR2 expression in FTs may serve as an early prediction sensor for ovarian cancer. We show now that knocking down Par2 inhibits ovarian cancer peritoneal dissemination in vivo, pointing serve as a powerful medicament in STICs and ovarian cancer.

, 2024 Abstract "Genetic heterogeneity in ovarian cancer indicates the need for personalised treatment To address the genetic heterogeneity of ovarian cancer, a future personalised approach could include cancer tissues. Subsequently, primary ovarian cancer cells derived from ascites and ovarian cancer cell lines were used However, the expression levels showed high variability within our selection of samples, therefore, supporting

cancer Published date August 15, 2023 Abstract "The long non-coding RNA (LncRNA) PAXIP1 antisense RNA 1 (PAXIP1-AS1) was found to promote proliferation, migration, EMT, and apoptosis of ovarian cancer ( infiltration of OC patients and its regulatory network are unclear. 379 OC tissues were collected from The Cancer Low PAXIP1-AS1 expression in OC was associated with age (P = 0.045), histological grade (P = 0.011), There were some genomic variations between the PAXIP1-AS1 high and low expression groups.

Cancer Date & Time Friday, November 3rd / 3:55 PM Abstract Coming Soon About Robert Rottapel "Dr. for Cancer Research. He has focussed on developing a comprehensive map of ovarian cancer essential genes using whole genome to buffer cancer associated stress states. pancreatic cancer.

cancer prognosis Published date June 18, 2024 Abstract " Background: Ovarian cancer (OV) is a common Method: We downloaded data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases The immunological characteristics of the high- and low-risk groups were analyzed using single-sample K-M analysis of the prognostic model showed that it could differentiate high- and low-risk patients, cancer , Prognostic model , epithelial Source Contribute to the GPCR News Coming soon Become a Contributor

cancer cells by targeting PAR-1 Published date June 21, 2024 Abstract "We have purified Peptidase M84 cancer cells. PAR-1, a GPCR which is reported to be overexpressed in ovarian cancer cells, was identified as a target This evoked apoptotic death of the ovarian cancer cells through the intrinsic route. cancer."

< GPCR News < GPCRs in Oncology and Immunology NPFF stimulates human ovarian cancer cell invasion by Epithelial ovarian cancer (EOC) is a leading cause of death among gynecological malignancies. Lanlan Fang , Peter C K Leung , Jung-Chien Cheng Tags Invasion , MMP-9 , NPFFR2 , Neuropeptide FF , Ovarian cancer Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

< GPCR News < GPCRs in Oncology and Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency crystalline nephropathy by increasing the oxalate intake of GPR4 KO and OGR1 KO mice.  After 10 days of high-oxalate

Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer One approach to treating patients suffering from lung cancer is to target surface receptors overexpressed , such as prostate and ovarian cancer, facilitating the invasive and metastatic capacity of tumor cells Since lung cancer is often diagnosed in advanced stages, our efforts should focus on early diagnosis, validating for example specific KLKs, especially in high-risk populations such as smokers and people

The GHRHR has recently been highlighted as a promising drug target toward several types of cancer and has been shown to be overexpressed in prostate, breast, pancreatic, and ovarian cancer. Indeed, peptide GHRHR antagonists have displayed promising results in many cancer models.

Oncology and Immunology Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer of receptors expression dynamics was performed for tumor-nodes-metastases (TNM) defined subgroups (ovarian

and Immunology Investigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer Published date November 1, 2022 Abstract Background: Breast cancer is the second leading cause of cancer-related Therefore, there is always an immense need to find promising and novel anti-cancer drug targets. Results: Isoform switching was observed at DCIS, grade 2 and grade 3, from canonical to the cub isoform Tags Breast cancer; EGFR; ERAD; RHBDF2; TACE; iRhom2.

the receptor tyrosine kinases family and overexpression of EGFR has been linked to poor prognosis and cancer SSTR2 and EGFR was evaluated by immunohistochemistry (IHC) in 491 cases of NPC and 50 cases of non-cancerous High expression of SSTR2 and EGFR was significantly increased in NPC patients compared with non-cancerous The study found that patients receiving chemoradiotherapy (CR) with high expression of SSTR2, high expression Interestingly, NPC patients with high expression of SSTR2, high expression of EGFR, high coexpression

< GPCR News < GPCRs in Oncology and Immunology Chemokine Physiology in Cancer Published date November In cancer, chemokines play paradoxical roles in both the directed emigration of metastatic, receptor-expressing cancer cells out of the tumor as well as immigration of tumor infiltrating immune cells that culminate Facets of chemokine physiology across discrete cancer immune phenotypes are contrasted to existing chemokine-centered therapies in cancer.

< GPCR News < GPCRs in Oncology and Immunology High expression of GPR50 promotes the proliferation, migration Previous studies have indicated that GPR50 could protect against breast cancer development and decrease

< GPCR News < GPCRs in Oncology and Immunology Esophageal and gastric cancer incidence trends in Golestan June 29, 2023 Abstract "Golestan province in the northeast of Iran is part of the Asian esophageal cancer belt and is known as a high-risk area for esophageal (EC) and gastric cancers (GC). on incident cases of EC and GC during 2004 to 2018 were obtained from the Golestan Population-based Cancer Despite favorable trends, this population remains at high risk of both EC and GC.

< GPCR News < GPCRs in Oncology and Immunology Pan-cancer functional analysis of somatic mutations in GPCRs) are the most frequently exploited drug target family, moreover they are often found mutated in cancer We explored cancer-related mutation patterns in all GPCR classes combined and individually. We subsequently created a ranking of high scoring GPCRs, using a multi-objective approach (Pareto Front families, but also discovered novel GPCRs which had not been linked to cancer before such as the P2Y

News < GPCRs in Oncology and Immunology Agonists of galanin subtype 2 receptor may prevent pancreatic cancer and agonists of angiotensin II type 2 receptor may prevent colorectal cancer Published date June 24, of colorectal carcinoma (CRC) is better than that of PDAC, it still is the second-leading cause of cancer receptor inhibited the growth of GAL2 receptor-expressing patient-derived xenografts (PDX) of pancreatic cancer lanthionine-constrained agonist of angiotensin II type 2 (AT2) receptor inhibited PDX of colorectal cancer

GPCRs in Oncology and Immunology Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling Published date June 21, 2024 Abstract "Colorectal cancer (CRC) remains a major global cause of cancer-related mortality, lacking effective biomarkers and therapeutic modulators play essential role within regulating downstream signaling of GPCR receptors, with function in cancers We confirmed the elevated RGS16 protein level in CRC, and found that patients with RGS16-high tumors

News < GPCRs in Oncology and Immunology The path of GPR87: from a P2Y-like receptor to its role in cancer Despite its high structural homology to several extracellular nucleotide-activated P2Y receptors and healthy ones clearly suggests that this receptor may be involved in the development and progression of cancerous expression of GPR87 as a predictive biomarker for evaluating the prognosis and overall survival of cancer

< GPCR News < GPCRs in Oncology and Immunology Short-chain fatty acids and cancer Published date December the microbiota, serve as crucial links between the diet, gut microbiota, metabolism, immunity, and cancer influencing tumor progression highlights the potential of targeting SCFA-mediated cellular processes for cancer Authors Shan Li, Yixin Duan, Shudi Luo, Fangxin Zhou, Qingang Wu, Zhimin Lu Tags acetate , butyrate , cancer

< GPCR News < GPCRs in Oncology and Immunology High Metabolite Concentrations in Portal Venous Blood show that the gut bacterial metabolites, short chain fatty acids (SCFAs), are present at exceptionally high Likely, many other metabolites will be present at high concentrations.

< GPCR News < GPCRs in Oncology and Immunology Biochemical pharmacology of adenylyl cyclases in cancer date October 1, 2024 Abstract "Globally, despite extensive research and pharmacological advancement, cancer Understanding the signaling pathways involved in cancer progression is essential for the discovery of The expression patterns of ACs in numerous cancers are discussed. , G protein , GPCR , Hallmarks of Cancer , cAMP signaling .

< GPCR News < GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer Published date March 11, 2023 Abstract belongs to the G protein-coupled receptor superfamily, which responds to external stimuli and regulates cancer progression, but its role in colorectal cancer (CRC) remains unclear. In the present study, expression analyses of GPR176 are performed in patients with colorectal cancer.

Consistent with its high specificity and stability, LP2 has shown excellent safety and pharmacokinetics rationales, we studied the capacity of LP2 to inhibit the growth of patient-derived xenografts of colorectal cancer on an untreated tissue array demonstrated that the AT 2 R expression is reduced in human colorectal cancer specificity, safety and stability, warrant further evaluation of LP2's inhibitory potential of colorectal cancer . " Authors P Namsolleck , L de Vries , G N Moll Tags AT(2)R , Agonist , Angiotensin , Cancer , GPCR

< GPCR News < GPCRs in Oncology and Immunology The landscape of cancer-rewired GPCR signaling axes Published