will be provided with Prism files, Excel templates and simulators, and the PowerPoints of the workshop modules Modules: Module 1 - Concentration-response analysis: Become a CRC super-user Module 2 - Quantifying agonist pharmacology and biased agonism Module 3 - Antagonist pharmacology and binding assay analysis Module 4 - New dimensions of activity: Allosteric modulators and kinetics Classes will be live from

Modules: Week 1 - Fundamentals of Pharmacology Week 2 - Characterizing Agonists Week 3 - Characterizing Antagonists Week 4 - Characterizing Allosteric Modulators Registrations start on December 15th and

Before the advent of AlphaFold, homology modeling was the most common method for predicting G protein-coupled Homology modeling relies on using the known structure of a homologous protein as a template to model For proteins with low sequence similarity to available templates, homology models tend to be less accurate targeting TAAR1, more than double that of the homology models. Ligand discovery from a dopamine D3 receptor homology model and crystal structure.

receptors (GPCRs), including the parathyroid hormone 1 receptor (PTH1R), a class B GPCR and an important modulator activation of PTH1R and its downstream signaling, we describe here that RAMP2 acts as a specific allosteric modulator Moreover, RAMP2 modulates PTH1R downstream signaling in an agonist-dependent manner, most notably increasing Employing homology modeling, we describe the putative structural molecular basis underlying our functional of RAMPs in the activation and signaling of a GPCR that may provide a new venue for highly specific modulation

The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of in vivo Animal models of CMV provide insights into their role in viral fitness. All cytomegalovirus (CMV) genomes analysed to date possess GPCR homologs with phylogenetic evidence for The mouse CMV (MCMV) GPCR homolog, designated M33, is important for cell-associated virus spread and

Genetic mouse models of CRC coupled with Gpr176-deficiency are investigated, and in vivo and in vitro GPR176 is confirmed to activate the cAMP/PKA signaling pathway and modulate mitophagy, promoting CRC A homolog model tool confirmed that GPR176 recruits GNAS intracellularly via its transmembrane helix Ji'ou Gu , Yifei Feng , Kangpeng Jin , Xiaowei Wang , Yueming Sun Tags GPCR , autophagy , growth , homology modeling , mitochondria.

GPCR News < GPCRs in Oncology and Immunology Involvement of Protease-Activated Receptor2 Pleckstrin Homology Previously we identified pleckstrin homology (PH) binding domains within PAR1,2&4 as critical sites for Bar-Shavit Tags G-protein coupled receptors (GPCRs) , fallopian tubes (FTs) , ovarian cancer , pleckstrin homology

2024 Abstract "Recent progress in elucidating the role of specific antidiuretic hormones in Drosophila models Xu et al. identified the mammalian neurokinin 3 receptor (TACR3), a homolog of the G protein-coupled We also acknowledged the limitations of current experimental models in this study and emphasized the