Genetic mouse models of CRC coupled with Gpr176-deficiency are investigated, and in vivo and in vitro GPR176 is confirmed to activate the cAMP/PKA signaling pathway and modulate mitophagy, promoting CRC A homolog model tool confirmed that GPR176 recruits GNAS intracellularly via its transmembrane helix Ji'ou Gu , Yifei Feng , Kangpeng Jin , Xiaowei Wang , Yueming Sun Tags GPCR , autophagy , growth , homology modeling , mitochondria.

GPCR News < GPCRs in Oncology and Immunology Involvement of Protease-Activated Receptor2 Pleckstrin Homology Previously we identified pleckstrin homology (PH) binding domains within PAR1,2&4 as critical sites for Bar-Shavit Tags G-protein coupled receptors (GPCRs) , fallopian tubes (FTs) , ovarian cancer , pleckstrin homology

2024 Abstract "Recent progress in elucidating the role of specific antidiuretic hormones in Drosophila models Xu et al. identified the mammalian neurokinin 3 receptor (TACR3), a homolog of the G protein-coupled We also acknowledged the limitations of current experimental models in this study and emphasized the

Agenda Session VIII * Physiological and pathological roles of AGPCRs in the periphery The CELSR/ADGRC Homolog role for CD97/ADGRE5 in the induction of allergic airway inflammation Gabriela Aust The CELSR/ADGRC Homolog Under nutrient depletion, the model choanoflagellate Salpingoeca rosetta forms distinct cell types that

hepatocellular carcinoma (HCC) was elucidated, and GPCR-related genes were employed for building a risk-score model genes (atypical chemokine receptor 3 (ACKR3), C-C chemokine receptor type 3 (CCR3), CCR7, frizzled homolog A clinical prediction model on the basis of GPCR-related risk scores was constructed. Conclusions: In this study, an efficient HCC prognostic prediction model was constructed by only GPCR-related

Both receptors contain PSD-95/Discs-large/ZO-1 homology (PDZ) motifs in their C-terminal tails through

They worked on the interactome of yeast and mammalian Rab5 homologs including identification of Rab5

< GPCR News < GPCRs in Oncology and Immunology Systems modeling of oncogenic G-protein and GPCR signaling unexpected differences in downstream pathway activation Published date July 16, 2024 Abstract "Mathematical models One promising potential application of such mathematical models is the study of how disease-causing mutations to be useful, but we hypothesized that mathematical modeling could be useful when there is incomplete In the present study, we first develop a mechanistic mathematical model of a G-protein coupled receptor

Immunology Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model clonal-expansion theory of cancer, e.g., as represented in the Moolgavkar-Venzon-Knudsen (MVK) cancer model carcinogenic (e.g., certain asbestos) fibers in humans and experimental animals are thought to involve modes cytotoxicity-associated inflammation, or both, rendering ambiguous expectations concerning the nature of model-implied

Committee Sponsors GPCR Retreat Program < Back to schedule Pharmacological and Genetic Preclinical Models

Here we used zebrafish and mouse models to probe the role of BLT2 in macrophage function during inflammation We detected BLT2 expression in bone marrow derived and peritoneal macrophages of mouse models. Using a zebrafish model of tailfin injury, we demonstrated that antisense morpholino-mediated knockdown We further replicated these findings in zebrafish models of islet injury and liver inflammation.

receptor (GPCR)-related genes and differentially expressed genes (DEGs) in an acute lung injury (ALI) model In an in vivo study, the effects of RGS6 knockout were studied in a mouse model of ALI induced by lipopolysaccharide and 49 congruously downregulated genes) were identified among GPCR-related genes and DEGs in the ALI model RGS6 was downregulated in vivo and in vitro in the ALI model.

Her next career step took her to AstraZeneca as a postdoctoral trainee, where she studied animal models Andrew Charles that who specialized in animal models of migraine and delta-opioid receptors as a therapeutic

To test this, an LFS mouse model (germline Tp53 deletion) with a second floxed allele under the control Preliminary findings indicate that the simultaneous loss of Bai3 and Tp53 expression in our mouse model A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development He is also interested in working on Glioma Brain Organoid models." native conditions, we strategically inserted specific mutations into the GAIN domain of the Latrophilin homologue

Herein we propose a model for immune conditioning, whereby metabolites such as butyrate affect immune This model helps explain how the gut microbiome may be affecting peripheral immune cells, and consequently

biased agonism, and incorporates computational and mathematical modelling, structural and chemical biology , molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease The conversation ended with Arthur's ongoing research and his development of a new operational model. model for allosteric modulation, emphasizing the balance between mechanism and empiricism. importance of establishing the correct disease context, setting up appropriate assays, and understanding the models

peptides such, as growth hormone-releasing hormone (GHRH), have been proposed to bind in a two-step model Indeed, peptide GHRHR antagonists have displayed promising results in many cancer models.

proteins by LPA, and by the related lipid mediator sphingosine-1-phosphate (S1P), in various cellular models In some model systems, CCN1 and CCN2 play key roles in LPA/S1P-induced cell migration and proliferation or S1P) can activate GPCR-mediated intracellular signaling to induce the production of extracellular modulators

conditional depletion on dendritic cell (DC-cKO), and keratin 14-conditional knockout (K14-cKO) mice models (IMQ)-induced GPR97-/- mice, which was consistent with the results in DC-cKO and K14-cKO psoriasis model

the molecular mechanisms of adhesion GPCRs (aGPCRs) in lymphatic endothelial cells (LECs), a cellular model

annual percentage change (EAPC) with 95 % confidence intervals (95 % CI) fitted age-period-cohort (APC) models Elisabete Weiderpass , Gholamreza Roshandel , Freddie Bray , Reza Malekzadeh Tags Age-Period-Cohort model

University in Australia, one of the pioneers in the medicinal chemistry, computational and mathematical modelling scientists working in the arenas of structure and signaling, neuroscience, cancer, translational and model

transmembrane receptors, combining biochemical and structural approaches with cell biology and in vivo models

computational structural biology tools and rational drug design approaches, ranging from molecular modeling

I work with invertebrate animal models (mainly D. melanogaster) and in vitro techniques to pick apart adhesion GPCRs, and extends to the development of novel screening approaches to identify pharmacological modulators

steroidogenesis in regulating sexual determination and adrenal and gonadal development using genetic mouse models

However, whether inflammation resolution is modulated by extracellular vesicles (EVs) and vesicular mediators Administration of efferocyte-derived EVs in a murine model of atherosclerosis is associated with an increase

approaches to explore the functional and therapeutic impacts of CB2 engagement on VAT ILC2s in a T2DM model