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592 items found for "immune cells"

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  • Profiling Immune Cell and Platelet Transcriptomes

    Additionally, the study identified unique expression patterns of GPCRs in different immune cell types , including B cells, CD4+ T cells, CD8+ T cells, natural killer (NK) cells, and dendritic cells. cell trafficking and inflammatory responses. The identification of a diverse array of GPCRs in immune cells underscores their potential roles in modulating Therefore this study significantly advances our understanding of GPCR expression in human immune cells

  • G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions...

    August 2022 G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions β-arrestin2 are key integrated signaling nodes in various biological processes, and both of them regulate cell proliferation and promote cell invasion and migration. This review summarizes the roles of GRK2/β-arrestin2 in immune cell function and focuses on the pathological

  • Immunomodulatory Role of Neuropeptides in the Cornea

    resident leukocyte populations make it an ideal tissue to study interactions between the nervous and immune The cornea is the most densely innervated tissue of the body and possesses both immune and vascular privilege , in part due to its unique repertoire of resident immune cells. Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells.

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  • Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions

    Immune cells commonly express two to four members of the GRK family (GRK2, GRK3, GRK5, GRK6) simultaneously , but we have very limited knowledge about their interplay in primary immune cells. Together, our findings demonstrate the complexity of GRK functions in immune cells, which go beyond GPCR Furthermore, they highlight the need for studying GRK functions in primary immune cells to address their ; GRK; T cells; dendritic cells; immune cell trafficking; leukocytes; neutrophils.

  • High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases

    Herein we propose a model for immune conditioning, whereby metabolites such as butyrate affect immune cells as they pass through the portal venous system. Deficiency of SCFA would lead to pro-inflammatory immune cell skewing through insufficient G-protein Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc This model helps explain how the gut microbiome may be affecting peripheral immune cells, and consequently

  • G protein coupled receptor transcripts in human immune cells and platelets

    < GPCR News < GPCRs in Oncology and Immunology G protein coupled receptor transcripts in human immune cells and platelets Published date September 27, 2024 Abstract "G-protein coupled receptors (GPCRs) We have used the method to profile GPCR transcripts in white blood cells (WBCs)-B, CD4, CD8, NK, and dendritic cells; monocytes, and macrophage-like monocytes treated with granulocyte-macrophage colony-stimulating On average, the white cells studied expressed 160 receptor mRNAs (range, 123-206).

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