August 2022 G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions β-arrestin2 are key integrated signaling nodes in various biological processes, and both of them regulate cell proliferation and promote cell invasion and migration. This review summarizes the roles of GRK2/β-arrestin2 in immune cell function and focuses on the pathological

resident leukocyte populations make it an ideal tissue to study interactions between the nervous and immune The cornea is the most densely innervated tissue of the body and possesses both immune and vascular privilege , in part due to its unique repertoire of resident immune cells. Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells.

August 2022 "Oxysterols induce the migration of B-lymphocytes and dendritic cells to interfollicular regions of lymphoid tissues through binding the EBI2 (GPR183) to stimulate effective adaptive immunity oxysterol binding site and the Gαi interface attenuate G protein signaling and abolish oxysterol-mediated cell

protein-coupled receptors (GPCRs) are essential contributors to tumor growth and metastasis due to their roles in immune cell regulation. Additionally, we focus on the roles of GPCRs in regulating immune checkpoint proteins involved in immune Authors Guang-Hong Qiu, Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy , immune cells , tumor microenvironment .

protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain human protein atlas database, we inferred the most predominant GPCR-mediated microbial metabolite-human cell interactions regulating gut-immune-brain axis. permeability of the small-molecules we elucidated their molecular interactions with specific human cell receptors, particularly expressed on human intestinal epithelial cells, immune cells and the nervous

transmitting signals inside the body, which is necessary for controlling the life activities of all cells , including tumor cells [1]. ATP functions as a mighty damage-linked molecular pattern when released outside the cell, accumulating protein-coupled receptors (GPCR) (P2Y) interact with ATP and other nucleotides, influencing diverse immune cell activities.