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30 items found for "immune infiltration"
- PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer
< GPCR News < GPCRs in Oncology and Immunology PAXIP1-AS1 is associated with immune infiltration and infiltration of OC patients and its regulatory network are unclear. 379 OC tissues were collected from regression, Kaplan-Meier method, Cox regression analysis, Gene set enrichment analysis (GSEA), and immuno-infiltration The expression of PAXIP1-AS1 was associated with immune infiltration. low expression of PAXIP1-AS1 was Low expression of PAXIP1-AS1 was significantly associated with poor survival and immune infiltration
- G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions
protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain inferred the most predominant GPCR-mediated microbial metabolite-human cell interactions regulating gut-immune-brain interactions with specific human cell receptors, particularly expressed on human intestinal epithelial cells, immune and metabolite cataloging with mechanistic studies for an improved understanding of gut microbiota-immune-brain Troyer , Suzi Hong Tags G protein-coupled receptors , Gut microbiota , Human-microbiota interactions , Immune
- The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor
hormones, neurotransmitters, and odorants, some of which play critical roles in innate and adaptive immune Here, we demonstrate that GPR141, an orphan GPCR belonging to the class A receptor family, suppresses immune increased CD11b + Gr1+ neutrophils, CD11b + Gr1- monocytes, CD11c+ dendritic cells, and CD4+ T cell infiltration Lymphocytes enriched from Gpr141 -/- mice immunized with myelin oligodendrocyte glycoprotein 35-55 produced These findings suggest that GPR141 functions as a negative regulator of immune responses by controlling
- Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning
< GPCR News < GPCRs in Oncology and Immunology Identification of S1PR4 as an immune modulator for favorable
- G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression
protein-coupled receptors (GPCRs) are essential contributors to tumor growth and metastasis due to their roles in immune Additionally, we focus on the roles of GPCRs in regulating immune checkpoint proteins involved in immune Authors Guang-Hong Qiu, Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy , immune cells , tumor microenvironment .
- CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus
GPCR News < GPCRs in Oncology and Immunology CB2 stimulation of adipose resident ILC2s orchestrates immune
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
promotes T cell dysfunction and cancer immunotherapy failure Published date June 12, 2023 Abstract "Immune G-protein-coupled receptors (GPCRs) are the most intensively studied drug targets but are underexplored in immuno-oncology These data indicate that Gαs-GPCRs are druggable immune checkpoints that might be targeted to enhance
- Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
SCI-IDS predominantly occurs following injury above the T5 levels and eventually leads to systemic immune and the HPA axis was explored by histology and multitissue transcriptomics, and the neuroendocrine-immune Results: The spleen and thymus gland, which are secondary immune organs, were significantly atrophied rt1-da, rt1-ba, cd74, cxcr3, vcam1, ccl5, bin1, and IL8) were significantly enriched in MHC-mediated immune this study assessed the differential regulation of the gene network associated with neuroendocrine immunity
- The power of many: Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer therapy
Despite their crucial role in regulating antitumor immunity and tumorigenesis, therapeutic applications the review highlights five GPCRs able to orchestrate tumor immunobiology at three main levels: tumor immunity Donato Inverso, Carlotta Tacconi, Serena Ranucci, Marco De Giovanni Tags Angiogenesis , Cancer , GPCRs , Immunity
- Metabolic crosstalk: Extracellular ATP and the tumor microenvironment in cancer progression and therapy
nucleotides to their respective di and mono-phosphate nucleoside forms, contributing significantly to immune protein-coupled receptors (GPCR) (P2Y) interact with ATP and other nucleotides, influencing diverse immune diminishing ATP-dependent activation and generating adenosine (ADO), potentially hindering antitumor immunity to devise strategies combating e-ATP/ADO-induced immunosuppression, ultimately enhancing anti-tumor immunity
- GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal pathway
dendritic cells (DCs) which can release interleukin 23 (IL-23) to interlink the innate and adaptive immunity knockout (K14-cKO) mice models to explore the function of GPR97 which influences keratinocytes and skin immunity Role of GPR97 is indispensable and this adhesion receptor may affect immune cell enrichment and function
- Ep 53 with Dr. Timo De Groof
He currently is focusing on the development of nanobody-based immuno tracers as part of the IMI/EFPIA project entitled "Immune Image".
- CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases
The CCR6/CCL20 axis plays a fundamental role in immune homeostasis and activation. Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy .
- Ep 85 with Nicholas Holliday
postdoctoral work that led to Nick's interest in peptide messengers regulating appetite, metabolism, and the immune
- Ep 126 with Dr. Françoise Bachelerie
activation/function of CXCR4-ACKR3 (CXCR7) receptors of the CXCL12 chemokine, key effectors of the immune
- CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration
sink for CCL19 to coordinate collective leukocyte migration Published date September 1, 2023 Abstract "Immune
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
druggable extracellular proteins, this axis plays essential roles in fibrosis, inflammation response and immune
- Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies
remodeling regulation of actin cytoskeleton organization by the kinase effectors of Rho GTPases" and "Immune
- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium
November 1, 2022 Abstract The rheumatoid arthritis (RA) inflammatory process occurs in the joints where immune
- AGPCR 24 Session VIII
Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 3. receptors impact cardiac structure and function, and has evolved to encompass their roles in regulating immune
- Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure
Here, we use validated and certified immune assays presenting native receptors as binding targets.
- Ep 146 with Dr Michael Feigin
GPCRs and Cancer Immune Modulation Yamina and Mike had a discussion about their research on GPCRs, specifically They also touched upon the potential of GPCR modulation in stimulating the immune system to fight cancer
- Ep 142 with Dr Claudia Stäubert
Our ultimate goal is to understand their role in immune cell function and cancer cell metabolism. " Dr
- Dr. GPCR Summit 2021 Live Talks
Learn More >> Hydroxycarboxylic acid receptor 3 and GPR84 signaling with potential implications for immune
- Ep 98 with Dr. GPCR Team
As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and immuno-oncology
- AGPCR 24 Session I
their signaling mechanisms is essential for the development of modulators for diseases such as cancer, immune
- Ep 60 with Dr. Josephine (Pina) Cardarelli
She has expertise in cell biology, pharmacology, translational medicine, oncology, immuno-oncology, immunology
- Ep 150 with Dr GPCR Team
As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and immuno-oncology