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interfollicular regions of lymphoid tissues through binding the EBI2 (GPR183) to stimulate effective adaptive immunity

cells and platelets, revealing significant findings that enhance our understanding of GPCRs' roles in immune Additionally, the study identified unique expression patterns of GPCRs in different immune cell types cell trafficking and inflammatory responses. immune responses and highlights the need for further functional studies to elucidate their specific receptors in monocytes and macrophages suggest that these GPCRs could be targeted to modulate inflammatory responses

2022 "The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of

< GPCR News < GPCRs in Oncology and Immunology Drosophila cytokine GBP2 exerts immune responses and regulates A functional analogue of GBP, stress-responsive peptide (SRP), was also identified in the same species It is expected that the biological responses of two structurally similar peptides should be coordinated Here, we demonstrate that GBP2 replicates the GBP1-mediated cellular immune response from Drosophila Our finding revealed that Drosophila GBP1 and GBP2 control immune responses as well as their own expression

and Immunology Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation Published date January 1, 2023 Abstract We recently This was linked with an increased inflammatory response in the Gpr101 deficient animals and a reduced Loss of Gpr101 on macrophages disrupted host pro-resolving responses to zymosan challenge with MacGpr101KO , Maria Gonzalez-Nunez , Ana Chopo-Pizarro , Jesmond Dalli Tags Acute inflammation , GPCR , Innate immunity

< GPCR News < GPCRs in Oncology and Immunology Chemoattractant receptor signaling in humoral immunity Published date April 4, 2024 Abstract "Efficient induction of humoral immune responses depends on orchestrated chemoattractant receptors and plays an important role in the control of B cell migration during humoral immune responses. summarize the current understanding of chemoattractant receptor signaling in the context of humoral immunity