interfollicular regions of lymphoid tissues through binding the EBI2 (GPR183) to stimulate effective adaptive immunity

cells and platelets, revealing significant findings that enhance our understanding of GPCRs' roles in immune Additionally, the study identified unique expression patterns of GPCRs in different immune cell types cell trafficking and inflammatory responses. immune responses and highlights the need for further functional studies to elucidate their specific receptors in monocytes and macrophages suggest that these GPCRs could be targeted to modulate inflammatory responses

2022 "The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of

prevent skin dysbiosis and bacterial infection "Healthy skin maintains a diverse microbiome and a potent immune This signaling axis was required for effective neutrophil-mediated skin immunity and microbiome homeostasis combating S. aureus infections and the formation of neutrophil abscesses, a hallmark of antibacterial immunity release of IL-1β and CXCL2 which are vital for proper amplification and propagation of the antibacterial immune response.

schizophrenia-relevant brain circuits "Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune

August 2022 G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions This review summarizes the roles of GRK2/β-arrestin2 in immune cell function and focuses on the pathological

resident leukocyte populations make it an ideal tissue to study interactions between the nervous and immune The cornea is the most densely innervated tissue of the body and possesses both immune and vascular privilege , in part due to its unique repertoire of resident immune cells. Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells.

with their receptors, are involved in various biologic processes and regulation of a wide range of immune responses in different physiologic and pathologic states such as tissue repair, infection, and inflammation

September 2022 "T cells are master regulators of the immune response tuning, among others, B cells, macrophages compartmentalization orchestrated in dynamic platforms is an essential requirement for the proper and efficient response Here, we discuss mechanisms responsible for signalling amplification and compartmentalization in T cell

receptor (GPCR), known as Mas-related G protein-coupled receptor-B2 (MRGPRB2), plays important roles in immune response.

mesenchymal stem cells in multiple sclerosis patients Multiple sclerosis (MS) is a specific type of chronic immune-mediated disease in which the immune responses are almost run against the central nervous system (CNS). Chemokine/chemokine receptor axes play a pivotal role in the recruitment and oriented trafficking of immune receptor axes network have crucial and efficacious impacts on behavior of the MSCs, nonetheless, the exact responsibility MSCs to migrate and home into the CNS of MS patients via expression of various chemokine receptors in response

provided a substantial body of evidence demonstrating that platelets also participate in host innate immunity interactions with neutrophils enhance neutrophil activation and are often crucial to induce a sufficient immune response.

October 2022 Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected Here, we revealed that dimerization of β2-AR is responsible for the constitutive activity of β2-AR generating

August 2022 GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists "In order to avoid a prolonged pro-inflammatory neutrophil response, signaling that regulate receptor phosphorylation and signaling termination, GRK2, which is highly expressed by immune

In CD8 + T cells, the chemokines promote unique transcriptional responses predicted to regulate inflammatory Our work demonstrates that differential subcellular signaling is critical to the overall biased response

Here, we revealed that dimerization of β2-AR is responsible for the constitutive activity of β2-AR generating

September 2022 GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response Besides, we found that GASP1 knockout obviously improved the response of breast cancer cells to paclitaxel demonstrates that GASP1 enhances malignant behaviors of breast cancer cells and decreases their cellular response

and internalization of G protein-coupled receptors (GPCRs) and it participates in inflammatory and immune responses that have been found to mediate apoptosis in autoimmune disease.

partner on GPCR-targeting antibodies GPCR Inhibition With ICB May Be Needed to Reactivate Antitumor Immune Response Garry Pairaudeau, CTO of Exscientia discuss transforming drug discovery using their AI-driven

September 2022 "The activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte response

Neuronal Gα subunits required for the control of response to polystyrene nanoparticles in the range of identify Gα proteins mediating function of neuronal G protein-coupled receptors (GPCRs) in controlling the response for understanding the important function of GPCRs-Gα signaling cascade in the neurons in controlling response

Another signaling pathway related to RGS4 involves the regulation of the immune response. RGS4 is expressed in various immune cells, including T cells and B cells, and has been shown to modulate immune cell activation and cytokine production. RGS4 acts as a negative regulator of T cell activation, and its expression is upregulated in response Wang, D., The essential role of G protein-coupled receptor (GPCR) signaling in regulating T cell immunity

adhesion GPCR Latrophilin, an adhesion GPCR with galactose-binding lectin domain involved in the innate immune response of Tribolium castaneum GPCR Activation and Signaling Biased allosteric activation of ketone transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response

specializing in the discovery and development of new drugs targeting G Protein-Coupled Receptors (GPCRs) in immuno-oncology

immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response.

Adhesion GPCRs Latrophilin, an adhesion GPCR with galactose-binding lectin domain involved in the innate immune response of Tribolium castaneum GPCR Activation and Signaling Palmitoylation of the Glucagon-like Peptide receptors GPCRs in Cardiology, Endocrinology, and Taste Beta cell primary cilia mediate somatostatin responsiveness

therapeutic modalities to modulate the stromal component, overcome chemotherapy resistance, and optimize immune responses and a comprehensive understanding of the role of the chemokine receptor system in different

in glioblastoma activated by acidic extracellular microenvironment Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10 Methods & Updates in GPCR Research