< GPCR News < GPCRs in Oncology and Immunology Drosophila cytokine GBP2 exerts immune responses and regulates A functional analogue of GBP, stress-responsive peptide (SRP), was also identified in the same species It is expected that the biological responses of two structurally similar peptides should be coordinated Here, we demonstrate that GBP2 replicates the GBP1-mediated cellular immune response from Drosophila Our finding revealed that Drosophila GBP1 and GBP2 control immune responses as well as their own expression

and Immunology Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation Published date January 1, 2023 Abstract We recently This was linked with an increased inflammatory response in the Gpr101 deficient animals and a reduced Loss of Gpr101 on macrophages disrupted host pro-resolving responses to zymosan challenge with MacGpr101KO , Maria Gonzalez-Nunez , Ana Chopo-Pizarro , Jesmond Dalli Tags Acute inflammation , GPCR , Innate immunity

< GPCR News < GPCRs in Oncology and Immunology Chemoattractant receptor signaling in humoral immunity Published date April 4, 2024 Abstract "Efficient induction of humoral immune responses depends on orchestrated chemoattractant receptors and plays an important role in the control of B cell migration during humoral immune responses. summarize the current understanding of chemoattractant receptor signaling in the context of humoral immunity

date April 29, 2024 Abstract "G protein-coupled receptors (GPCRs) regulate many cellular processes in response hormones, neurotransmitters, and odorants, some of which play critical roles in innate and adaptive immune responses. responses. These findings suggest that GPR141 functions as a negative regulator of immune responses by controlling

from the diet and the microbiota, serve as crucial links between the diet, gut microbiota, metabolism, immunity pathways, and gene expression in cells within the tumor microenvironment, particularly in tumor and immune Duan, Shudi Luo, Fangxin Zhou, Qingang Wu, Zhimin Lu Tags acetate , butyrate , cancer , cell death , immune response , metabolism , proliferation , propionate , short chain fatty acid Source Contribute to the

Adenosine 2a receptor (A2aR), a typical GPCR with a high affinity for adenosine, is widely expressed on immune cells, inhibiting anti-tumor immune response accordingly.

GPCRRG expression was correlated with immune infiltration rates. prognostic model elaborates on the roles of GPCRRGs in OV and provides a new tool for prognosis and immune response prediction in patients with OV." Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled receptor , Immune

sink for CCL19 to coordinate collective leukocyte migration Published date September 1, 2023 Abstract "Immune responses rely on the rapid and coordinated migration of leukocytes. (DCs) effectively internalize the receptor and ligand as part of the canonical GPCR desensitization response

GPCRs) are essential for sensing chemokine gradients and directing the movement of leukocytes during immune responses. -bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3) to spatiotemporally control immune

CCRs were significantly induced in spleen of largemouth bass, indicating their important roles in the immune response against bacterial infection.

remodeling regulation of actin cytoskeleton organization by the kinase effectors of Rho GTPases" and "Immune response B cell antigen receptor (BCR) pathway".

SCI-IDS predominantly occurs following injury above the T5 levels and eventually leads to systemic immune and the HPA axis was explored by histology and multitissue transcriptomics, and the neuroendocrine-immune Results: The spleen and thymus gland, which are secondary immune organs, were significantly atrophied rt1-da, rt1-ba, cd74, cxcr3, vcam1, ccl5, bin1, and IL8) were significantly enriched in MHC-mediated immune responses.

proteins and kinases in T-cell migration and provides potential novel targets for modulation of the T-cell immune response."

These findings provide a better understanding of the role of IL-8 in PEDV-induced immune responses, which

< GPCR News < GPCRs in Oncology and Immunology PAXIP1-AS1 is associated with immune infiltration and lines, but the relationship between PAXIP1-AS1 expression and clinical characteristics, prognosis, and immune The expression of PAXIP1-AS1 was associated with immune infiltration. low expression of PAXIP1-AS1 was Low expression of PAXIP1-AS1 was significantly associated with poor survival and immune infiltration PAXIP1-AS1 could be a promising prognosis biomarker and response to immunotherapy for OC."

GPCRs in Oncology and Immunology Combinatorial depletions of G-protein coupled receptor kinases in immune , but we have very limited knowledge about their interplay in primary immune cells. Neutrophils lacking all four GRK family members show increased chemotactic migration responses to a wide range of GPCR ligands, whereas combinatorial GRK depletions in other immune cell types lead to pro- and anti-migratory responses.

Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune Herein we propose a model for immune conditioning, whereby metabolites such as butyrate affect immune Deficiency of SCFA would lead to pro-inflammatory immune cell skewing through insufficient G-protein Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc Western lifestyle diseases, most of which are immune based, in tissues remote from the gut."

< GPCR News < GPCRs in Oncology and Immunology GPCR signaling contributes to immune characteristics of Our multi-omics analysis of NKTCL revealed that EBV gene pattern correlated with immune-related oncogenic Single-cell transcriptome further delineated the tumor microenvironment as immune-inflamed, -deficient , and -desert phenotypes, in association with different setpoints of cancer-immunity cycle.

protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain inferred the most predominant GPCR-mediated microbial metabolite-human cell interactions regulating gut-immune-brain interactions with specific human cell receptors, particularly expressed on human intestinal epithelial cells, immune and metabolite cataloging with mechanistic studies for an improved understanding of gut microbiota-immune-brain Troyer , Suzi Hong Tags G protein-coupled receptors , Gut microbiota , Human-microbiota interactions , Immune

Contest Committee Sponsors GPCR Retreat Program < Back to schedule Targeting adenosine signaling for immuno-oncology signaling through A2A and A2B G protein-coupled receptors is increasingly recognized as an important immune checkpoint in the generation of anti-tumor immunity. and adenosine signaling and discuss unexpected links between the adenosinergic pathway, DNA damage response identified the adenosine-producing enzyme CD73 as a new cancer target, and for his translational work in immuno-oncology

receptors and non-GPCR binding partners that cumulatively influence discrete pharmacological signaling responses metastatic, receptor-expressing cancer cells out of the tumor as well as immigration of tumor infiltrating immune cells that culminate in a tumor unique immune microenvironment. Facets of chemokine physiology across discrete cancer immune phenotypes are contrasted to existing chemokine-centered Authors Donovan Drouillard, Brian T Craig, Michael B Dwinell Tags Chemokine receptor; cell migration; immuno-oncology

< GPCR News < GPCRs in Oncology and Immunology G protein coupled receptor transcripts in human immune

promotes T cell dysfunction and cancer immunotherapy failure Published date June 12, 2023 Abstract "Immune However, many cancers do not respond to ICB, prompting the search for additional strategies to achieve durable responses. These data indicate that Gαs-GPCRs are druggable immune checkpoints that might be targeted to enhance the response to ICB immunotherapies. © 2023.

< GPCR News < GPCRs in Oncology and Immunology Identification of S1PR4 as an immune modulator for favorable

GPCR News < GPCRs in Oncology and Immunology CB2 stimulation of adipose resident ILC2s orchestrates immune

protein-coupled receptors (GPCRs) are essential contributors to tumor growth and metastasis due to their roles in immune Additionally, we focus on the roles of GPCRs in regulating immune checkpoint proteins involved in immune Authors Guang-Hong Qiu, Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy , immune cells , tumor microenvironment .

Oncology and Immunology Itaconate in host inflammation and defense Published date March 5, 2024 Abstract "Immune to and regulates the function of diverse proteins intracellularly to influence metabolism, oxidative response Administration of ITA protects against inflammatory diseases and blockade of ITA production enhances antitumor immunity

Despite their crucial role in regulating antitumor immunity and tumorigenesis, therapeutic applications the review highlights five GPCRs able to orchestrate tumor immunobiology at three main levels: tumor immunity Donato Inverso, Carlotta Tacconi, Serena Ranucci, Marco De Giovanni Tags Angiogenesis , Cancer , GPCRs , Immunity