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schizophrenia-relevant brain circuits "Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging evidence points to CB2 playing a key role in regulating neuronal function in the central nervous system.

September 2022 "The endocannabinoid system plays a key role in the intersection of the nervous, endocrine , and immune systems, regulating not only their functions but also how they interplay with each other It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of cell wall, disrupt not only the hypothalamic–pituitary–adrenal axis but also affects other endocrine systems

Scientific Data by Arne Hansen et a l has introduced a sensitive method for detecting GPCR mRNAs in human immune cells and platelets, revealing significant findings that enhance our understanding of GPCRs' roles in immune Additionally, the study identified unique expression patterns of GPCRs in different immune cell types immune responses and highlights the need for further functional studies to elucidate their specific Therefore this study significantly advances our understanding of GPCR expression in human immune cells

interfollicular regions of lymphoid tissues through binding the EBI2 (GPR183) to stimulate effective adaptive immunity

resident leukocyte populations make it an ideal tissue to study interactions between the nervous and immune systems. , in part due to its unique repertoire of resident immune cells. Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells. surface, alterations in disease settings, and the possible therapeutic potential of targeting these systems

prevent skin dysbiosis and bacterial infection "Healthy skin maintains a diverse microbiome and a potent immune system to fight off infections. This signaling axis was required for effective neutrophil-mediated skin immunity and microbiome homeostasis combating S. aureus infections and the formation of neutrophil abscesses, a hallmark of antibacterial immunity release of IL-1β and CXCL2 which are vital for proper amplification and propagation of the antibacterial immune

October 2022 "Perturbation of the endocannabinoid system can have profound effects on immune function Microglia are one of few cell types with a self-contained endocannabinoid system and are positioned at the interface between the immune system and the central nervous system. results with respect to the effects of pro-inflammatory conditions on the microglial endocannabinoid system stimuli, lipopolysaccharide and interferon gamma, on the abundance of components of the endocannabinoid system

August 2022 G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions This review summarizes the roles of GRK2/β-arrestin2 in immune cell function and focuses on the pathological

cells expressing the chemokine receptor endogenously together with relevant enzymes and co-receptor systems our understanding on the dynamics and biological relevance of these PTMs in the chemokine receptor system which may ultimately allow for new precise targeting of the immune system.

The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation However, an imbalance in the chemokine system can also contribute to various diseases, such as inflammatory glycosaminoglycans (GAGs) to regulate the movement of leukocytes throughout the body, ensuring a functional immune system and an effective response to inflammatory stimuli (Proudfoot, A.

Herein, we identified GPR108, a GPCR protein described in innate immune system, is a potential therapeutic

S1P5 is predominantly expressed in nervous and immune systems, regulating the egress of natural killer cells from lymph nodes and playing a role in immune and neurodegenerative disorders, as well as carcinogenesis

belong to a subfamily of G-protein-coupled receptors (GPCRs) and play a crucial role in inflammation and immune The chemokine system exhibits great versatility, with more than 50 chemokines interacting with over 20 receptor-chemokine complexes and revealing the diverse and multifaceted nature of the chemokine receptor system study of all structures of CKRs characterizes the molecular recognition processes governing the CKR system experimental structures of chemokine receptors, which provide insights into the complexity of the chemokine system

GPR84 is a G protein-coupled receptor primarily expressed in myeloid cells that constitute the innate immune system, including neutrophils, monocytes, and macrophages in the periphery and microglia in the brain These results define a unique role of GPR84 in innate immune cells and intestinal inflammation, and suggest

The molecular mechanisms N. meningitidis employ to manipulate the immune system, translocate the mucosal

September 2022 "Systemic sclerosis (SSc) is a systemic autoimmune disease with the key features of inflammation

September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer "Quantitative systems pharmacology (QSP) modeling is nab-paclitaxel has shown clinical activity in advanced TNBC with PD-L1-positive tumor-infiltrating immune As tumor-associated macrophages (TAMs) serve as major contributors to the immuno-suppressive tumor microenvironment

Although they form an ancient signaling system, there is still a great deal of variety in neuropeptides By comparison, we found that the Releasing Hormone-Related Peptides (GnRHs) system of Sternorrhyncha Additionally, we discovered that the neuropeptide signaling systems of Sternorrhyncha were very different This research provides more knowledge on neuropeptide systems and sets the groundwork for the creation

August 2022 "Host response to infection involves the activation of the complement system leading to the

between antagonist, partial agonist, and biased agonist outcomes in various primary and clonal cell systems

GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health of the physiological balance between healthy and pathological conditions; thus, their importance in systems The molecular diversity of GPCR signaling systems is likely to be closely associated with disease-associated compartmentalization, thus enabling a nuanced GPCR-based capacity to interdict multiple disease pathomechanisms at a systemic

August 2022 "The calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid pregnenolone sulfate. TRPM3's best understood function is its role as a peripheral noxious heat sensor in mice. However, the channel is expressed in various tissues and cell types including neurons as well as glial and epithelial cells. TRPM3 expression patterns differ between species and change during development. Furthermore, a plethora of TRPM3 variants that result from alternative splicing have been identified and the majority of these isoforms are yet to be characterized. Moreover, the mechanisms underlying regulation of TRPM3 are largely unexplored. In addition, a micro-RNA gene (miR-204) is located within the TRPM3 gene. This complexity makes it difficult to obtain a clear picture of TRPM3 characteristics. However, a clear picture is needed to unravel TRPM3's full potential as experimental tool, diagnostic marker and therapeutic target. Therefore, the newest data related to TRPM3 have to be discussed and to be put in context as soon as possible to be up-to-date and to accelerate the translation from bench to bedside. The aim of this review is to highlight recent results and developments with particular focus on findings from studies involving ocular tissues and cells or peripheral neurons of rodents and humans." Read more at the source #DrGPCR #GPCR #IndustryNews

Coordinated transcriptomics and peptidomics of central nervous system identify neuropeptides and their Here, we generated a transcriptome of the central nervous system (CNS) of G. molesta.

September 2022 "Perception of threats is essential for survival. Previous findings suggest that parallel pathways independently relay innate threat signals from different sensory modalities to multiple brain areas, such as the midbrain and hypothalamus, for immediate avoidance. Yet little is known about whether and how multi-sensory innate threat cues are integrated and conveyed from each sensory modality to the amygdala, a critical brain area for threat perception and learning. Here, we report that neurons expressing calcitonin gene-related peptide (CGRP) in the parvocellular subparafascicular nucleus in the thalamus and external lateral parabrachial nucleus in the brainstem respond to multi-sensory threat cues from various sensory modalities and relay negative valence to the lateral and central amygdala, respectively. Both CGRP populations and their amygdala projections are required for multi-sensory threat perception and aversive memory formation. The identification of unified innate threat pathways may provide insights into developing therapeutic candidates for innate fear-related disorders." Read more at the source #DrGPCR #GPCR #IndustryNews

specializing in the discovery and development of new drugs targeting G Protein-Coupled Receptors (GPCRs) in immuno-oncology

of small molecules against cannabinoid 2 receptor (CB2R) Ketone bodies as chemical signals for the immune system AI-driven GPCR analysis, engineering, and targeting Structural and Molecular Insights into GPCR

Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases Lactate receptor GPR81 drives breast cancer growth and invasiveness through

In the cardiovascular system, ORs have the potential to operate as the main carriers of endogenously In the immune system ORs are expressed in different blood cells where aroma compounds from butter, known In the gastrointestinal system, ORs may significantly contribute to abnormal bowel functions. In the nervous system, although there is limited data, it has been suggested that ORs adopt functions in the central nervous system.