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Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases Published date November 20, 2023 Abstract "We show that the gut bacterial Herein we propose a model for immune conditioning, whereby metabolites such as butyrate affect immune cells as they pass through the portal venous system. Western lifestyle diseases, most of which are immune based, in tissues remote from the gut."

protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain cells and the nervous system that are shown to hold much promise for clinical translational potential and metabolite cataloging with mechanistic studies for an improved understanding of gut microbiota-immune-brain Troyer , Suzi Hong Tags G protein-coupled receptors , Gut microbiota , Human-microbiota interactions , Immune system , Inflammation , Metabolites Source Contribute to the GPCR News Coming soon Become a Contributor

postdoctoral work that led to Nick's interest in peptide messengers regulating appetite, metabolism, and the immune system, and the molecular mechanisms underlying the signaling and regulation of their GPCRs.

The CCR6/CCL20 axis plays a fundamental role in immune homeostasis and activation. Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy .

activation/function of CXCR4-ACKR3 (CXCR7) receptors of the CXCL12 chemokine, key effectors of the immune system, including their role in immunological disorders (e.g.

In this setting, OGR1 KO mice displayed an increased activation of the immune system and a higher production

< GPCR News < GPCRs in Oncology and Immunology Chemoattractant receptor signaling in humoral immunity Published date April 4, 2024 Abstract "Efficient induction of humoral immune responses depends on orchestrated chemoattractant receptors and plays an important role in the control of B cell migration during humoral immune summarize the current understanding of chemoattractant receptor signaling in the context of humoral immunity

< GPCR News < GPCRs in Oncology and Immunology PAXIP1-AS1 is associated with immune infiltration and lines, but the relationship between PAXIP1-AS1 expression and clinical characteristics, prognosis, and immune regression, Kaplan-Meier method, Cox regression analysis, Gene set enrichment analysis (GSEA), and immuno-infiltration The expression of PAXIP1-AS1 was associated with immune infiltration. low expression of PAXIP1-AS1 was Low expression of PAXIP1-AS1 was significantly associated with poor survival and immune infiltration

GPCRs in Oncology and Immunology Combinatorial depletions of G-protein coupled receptor kinases in immune Immune cells commonly express two to four members of the GRK family (GRK2, GRK3, GRK5, GRK6) simultaneously , but we have very limited knowledge about their interplay in primary immune cells. cell types (neutrophils, T cells, B cells and dendritic cells) and systematically addressed the functional Together, our findings demonstrate the complexity of GRK functions in immune cells, which go beyond GPCR

< GPCR News < GPCRs in Oncology and Immunology GPCR signaling contributes to immune characteristics of Our multi-omics analysis of NKTCL revealed that EBV gene pattern correlated with immune-related oncogenic Single-cell transcriptome further delineated the tumor microenvironment as immune-inflamed, -deficient , and -desert phenotypes, in association with different setpoints of cancer-immunity cycle.

David Tuveson at CSHL where he participated in the development of an organoid system for the culture Mike also spoke about his initial struggles during his Ph.D., such as a difficult model system and a GPCRs and Cancer Immune Modulation Yamina and Mike had a discussion about their research on GPCRs, specifically They also touched upon the potential of GPCR modulation in stimulating the immune system to fight cancer

< GPCR News < GPCRs in Oncology and Immunology Drosophila cytokine GBP2 exerts immune responses and regulates Here, we demonstrate that GBP2 replicates the GBP1-mediated cellular immune response from Drosophila Our finding revealed that Drosophila GBP1 and GBP2 control immune responses as well as their own expression levels through a hierarchical cytokine network, indicating that Drosophila GBP1/GBP2 system can be a

Chemokines are a physiologic system that is finely tuned by ligand and receptor expression, ligand or metastatic, receptor-expressing cancer cells out of the tumor as well as immigration of tumor infiltrating immune cells that culminate in a tumor unique immune microenvironment. Facets of chemokine physiology across discrete cancer immune phenotypes are contrasted to existing chemokine-centered Authors Donovan Drouillard, Brian T Craig, Michael B Dwinell Tags Chemokine receptor; cell migration; immuno-oncology

< GPCR News < GPCRs in Oncology and Immunology G protein coupled receptor transcripts in human immune

Contest Committee Sponsors GPCR Retreat Program < Back to schedule Targeting adenosine signaling for immuno-oncology signaling through A2A and A2B G protein-coupled receptors is increasingly recognized as an important immune checkpoint in the generation of anti-tumor immunity. identified the adenosine-producing enzyme CD73 as a new cancer target, and for his translational work in immuno-oncology immunotherapies, and member of the SAB of Domain Therapeutics, a biopharmaceutical company focused on GPCR in immuno-oncology

< GPCR News < GPCRs in Oncology and Immunology Identification of S1PR4 as an immune modulator for favorable

and Immunology Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune , Maria Gonzalez-Nunez , Ana Chopo-Pizarro , Jesmond Dalli Tags Acute inflammation , GPCR , Innate immunity

motor function in the body below the level of injury, is a devastating disease of the central nervous system SCI-IDS predominantly occurs following injury above the T5 levels and eventually leads to systemic immune and the HPA axis was explored by histology and multitissue transcriptomics, and the neuroendocrine-immune Results: The spleen and thymus gland, which are secondary immune organs, were significantly atrophied Neuraxial nerve inflammation caused by SCI persists indefinitely, blocking nerve repair; persistent system-wide

GPCR News < GPCRs in Oncology and Immunology CB2 stimulation of adipose resident ILC2s orchestrates immune Here, we demonstrate that CB2, a G-protein-coupled receptor (GPCR) and member of the endocannabinoid system

protein-coupled receptors (GPCRs) are essential contributors to tumor growth and metastasis due to their roles in immune Additionally, we focus on the roles of GPCRs in regulating immune checkpoint proteins involved in immune Authors Guang-Hong Qiu, Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy , immune cells , tumor microenvironment .

hormones, neurotransmitters, and odorants, some of which play critical roles in innate and adaptive immune physiological functions of many GPCRs and the involvement of them in autoimmune diseases of the central nervous system Here, we demonstrate that GPR141, an orphan GPCR belonging to the class A receptor family, suppresses immune Lymphocytes enriched from Gpr141 -/- mice immunized with myelin oligodendrocyte glycoprotein 35-55 produced These findings suggest that GPR141 functions as a negative regulator of immune responses by controlling

treatment of obesity and Type 2 Diabetes (T2D) by exploring metabolically important signaling pathways in immune His laboratory uses knock-out and transgenic mouse models, along with different cell culture systems, to understand the role of immune cell GPCRs and their cross-talk with other insulin-sensitive tissues

2024 Abstract " Background: Ovarian cancer (OV) is a common malignant tumor of the female reproductive system GPCRRG expression was correlated with immune infiltration rates. prognostic model elaborates on the roles of GPCRRGs in OV and provides a new tool for prognosis and immune Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled receptor , Immune

promotes T cell dysfunction and cancer immunotherapy failure Published date June 12, 2023 Abstract "Immune G-protein-coupled receptors (GPCRs) are the most intensively studied drug targets but are underexplored in immuno-oncology These data indicate that Gαs-GPCRs are druggable immune checkpoints that might be targeted to enhance

from the diet and the microbiota, serve as crucial links between the diet, gut microbiota, metabolism, immunity pathways, and gene expression in cells within the tumor microenvironment, particularly in tumor and immune Duan, Shudi Luo, Fangxin Zhou, Qingang Wu, Zhimin Lu Tags acetate , butyrate , cancer , cell death , immune

Despite their crucial role in regulating antitumor immunity and tumorigenesis, therapeutic applications the review highlights five GPCRs able to orchestrate tumor immunobiology at three main levels: tumor immunity Donato Inverso, Carlotta Tacconi, Serena Ranucci, Marco De Giovanni Tags Angiogenesis , Cancer , GPCRs , Immunity

nucleotides to their respective di and mono-phosphate nucleoside forms, contributing significantly to immune protein-coupled receptors (GPCR) (P2Y) interact with ATP and other nucleotides, influencing diverse immune diminishing ATP-dependent activation and generating adenosine (ADO), potentially hindering antitumor immunity to devise strategies combating e-ATP/ADO-induced immunosuppression, ultimately enhancing anti-tumor immunity

between GPR37 gene expression and the clinicopathological factors, patient prognosis, tumor-infiltrating immune clinical relevance, and molecular function of GPR37 in glioma using TCGA, STRING, cBioPortal, Tumor Immunity Besides, the "ssGSEA" algorithm was conducted to estimate immune cells infiltration abundance, with ' Furthermore, GPR37 was positively correlated with various immune checkpoints (ICPs). Lai , Huaidong Peng , Yanbin Ke , Zhaotao Wang , Yezhong Wang Tags GPR37 , M2 macrophages , glioma , immune