new antifibrotic cGAS/STING signaling pathway that suppresses pathological angiogenesis in liver and kidney We showed that cGAS expression was induced in fibrotic liver and kidney, but suppressed in endothelial cells. cGAS genetic deletion promoted liver and kidney fibrosis and pathological angiogenesis, including GPCR)-based antagonist that blocks the profibrotic activity of endothelial YAP, attenuated liver and kidney Further, pharmacological targeting of cGAS/STING-YAP axis exhibits the potential to alleviate liver and kidney

Here, we show that human GPR125 likely undergoes cis-autoproteolysis when expressed in canine kidney epithelial MDCK cells and human embryonic kidney HEK293 cells.

development, PGE2 signaling regulates embryogenesis, hepatocyte differentiation, hematopoiesis, and kidney

Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates crystal deposition and kidney When lowering the severity of the kidney injury, OGR1 KO mice were more prone to develop crystalline OGR1 deficiency, however, increases crystal deposition leading to impaired kidney function. for the pathophysiology of oxalate kidney stones or other crystallopathies." disease , hyperoxaluria , inflammation , kidney stones Source Contribute to the GPCR News Coming soon

Jinqiancao granules are a traditional Chinese medicine used to treat kidney stones and this medicine

Immunology Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney 28, 2023 Abstract " Background and purpose: Activated fibroblasts deposit fibrotic matrix in chronic kidney Here, we set out to establish a transcriptional profile that identifies activated kidney fibroblasts Correlative histology was performed in human kidney tissue. Tags Adenosine receptor , Fibroblast , Fibrosis , GPCR , Kidney , Tcf21 .