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29 items found for "kidney stones"
- Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and...
new antifibrotic cGAS/STING signaling pathway that suppresses pathological angiogenesis in liver and kidney We showed that cGAS expression was induced in fibrotic liver and kidney, but suppressed in endothelial cells. cGAS genetic deletion promoted liver and kidney fibrosis and pathological angiogenesis, including GPCR)-based antagonist that blocks the profibrotic activity of endothelial YAP, attenuated liver and kidney Further, pharmacological targeting of cGAS/STING-YAP axis exhibits the potential to alleviate liver and kidney
- GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral...
Here, we show that human GPR125 likely undergoes cis-autoproteolysis when expressed in canine kidney epithelial MDCK cells and human embryonic kidney HEK293 cells.
- Prostaglandin signaling in ciliogenesis and development
development, PGE2 signaling regulates embryogenesis, hepatocyte differentiation, hematopoiesis, and kidney
- The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum
- Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice
injected PTH analog peptides that are consistent with a fully functional human PTH1R in target bone and kidney
- Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C...
In this study, we generated and characterized human embryonic kidney 293A (HEK293A) cell lines devoid
- 📰 GPCR Weekly News, July 10 to 16, 2023
Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates crystal deposition and kidney
- 📰 GPCR Weekly News, October 9 to 15, 2023
Nobel Laureates Highlight Symposium Celebrating Lefkowitz’s 50 Years at Duke Novo Nordisk stops Ozempic kidney
- 📰 GPCR Weekly News
Phase 2 Trial of INV-202, an Oral, Peripherally-acting CB1 Inverse Agonist, in Patients with Diabetic Kidney
- All Aboard the GPCR Express: Your Weekly Update is here! Oct 14-20, 2024
substitutions and recurrent gene loss in sauropsids Noval insights and therapeutic strategies for tumor-induced kidney
- 📰 GPCR Weekly News, July 24 to July 30, 2023
ion transients evoked by cell poking independently of released autocrine ATP in Madin-Darby canine kidney
- 📰 GPCR Weekly News, March 20 to 26, 2023
Endocrinology, and Taste Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney
- 📰 GPCR Weekly News, May 20 to 26, 2024
Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys
- 📰 Breaking Down the Latest GPCR Discoveries: a Weekly Update (Nov 27-Dec 3, 2023)
NMR spectroscopy Role of protease activated receptor 4 (PAR4) in mouse models of acute and chronic kidney
- 📰 GPCR Weekly News, April 24 to 30, 2023
Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney
- 📰 GPCR Weekly News, November 13 to 19, 2023
Butyrate induces STAT3/HIF-1α/IL-22 signaling via GPCR and HDAC3 inhibition to activate autophagy in head kidney
- 📰 GPCR Weekly News, January 15 to 21, 2024
Targeting Giα1/3 APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney
- 📰 GPCR Weekly News
FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury
- 📰 GPCR Weekly News, October 30 to November 4, 2023
Minor Effects on Cardiac Hypertrophy Single cell G-protein coupled receptor profiling of activated kidney
- Unlock the Future of GPCR Science: Breakthroughs and Courses Await | Sep 2 - Sep 8, 2024
downregulation GPCRs in Cardiology, Endocrinology, and Taste Role of G protein coupled receptors in acute kidney
- Odorant receptors – a bit of smell for drug discovery
In the human kidney ORs elicit intracellular Ca2+flux in renal proximal tubule cells via adenylyl cyclase
- The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1
August 2022 "Background and purpose: Vascular tone is regulated by the relative contractile state of
- Melatonin MT 2 receptor is expressed and potentiates contraction in human airway smooth muscle
intracellular cyclic AMP (cAMP) and calcium concentrations ([Ca2+]i), which modulate airway smooth muscle tone findings suggest that the melatonin MT2 receptor is expressed in ASM, and modulates airway smooth muscle tone
- Glyco-sulfo hotspots in the chemokine receptor system
the negative sulfate groups in the N-terminus and the positively charged chemokines (Ludeman JP and Stone
- Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling
mediated activation, which subsequently transactivates purinergic receptors through Gq in intracellular stores
- From DNA day to GPCR genomics
It provided a fundamental understanding of how genetic information is stored and transferred between
- GPCR Buzz of the Week | Sep 23 - 29, 2024
Enhance Azobenzene-Based Photopharmacology GPCRs in Cardiology, Endocrinology, and Taste Rap1A Modulates Store-Operated
- Adhesion GPCR Consortium Newsletter - May 2024
will likely bring together some of the hottest adhesion GPCR research going on right now and set the tone