new antifibrotic cGAS/STING signaling pathway that suppresses pathological angiogenesis in liver and kidney We showed that cGAS expression was induced in fibrotic liver and kidney, but suppressed in endothelial cells. cGAS genetic deletion promoted liver and kidney fibrosis and pathological angiogenesis, including GPCR)-based antagonist that blocks the profibrotic activity of endothelial YAP, attenuated liver and kidney Further, pharmacological targeting of cGAS/STING-YAP axis exhibits the potential to alleviate liver and kidney

Here, we show that human GPR125 likely undergoes cis-autoproteolysis when expressed in canine kidney epithelial MDCK cells and human embryonic kidney HEK293 cells.

development, PGE2 signaling regulates embryogenesis, hepatocyte differentiation, hematopoiesis, and kidney

TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum

injected PTH analog peptides that are consistent with a fully functional human PTH1R in target bone and kidney

In this study, we generated and characterized human embryonic kidney 293A (HEK293A) cell lines devoid

Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates crystal deposition and kidney

Nobel Laureates Highlight Symposium Celebrating Lefkowitz’s 50 Years at Duke Novo Nordisk stops Ozempic kidney

Phase 2 Trial of INV-202, an Oral, Peripherally-acting CB1 Inverse Agonist, in Patients with Diabetic Kidney

substitutions and recurrent gene loss in sauropsids Noval insights and therapeutic strategies for tumor-induced kidney

ion transients evoked by cell poking independently of released autocrine ATP in Madin-Darby canine kidney

Endocrinology, and Taste Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney

Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys

NMR spectroscopy Role of protease activated receptor 4 (PAR4) in mouse models of acute and chronic kidney

Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney

Butyrate induces STAT3/HIF-1α/IL-22 signaling via GPCR and HDAC3 inhibition to activate autophagy in head kidney

Targeting Giα1/3 APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney

FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury

Minor Effects on Cardiac Hypertrophy Single cell G-protein coupled receptor profiling of activated kidney

downregulation GPCRs in Cardiology, Endocrinology, and Taste Role of G protein coupled receptors in acute kidney

In the human kidney ORs elicit intracellular Ca2+flux in renal proximal tubule cells via adenylyl cyclase

August 2022 " Background and purpose: Vascular tone is regulated by the relative contractile state of

intracellular cyclic AMP (cAMP) and calcium concentrations ([Ca2+]i), which modulate airway smooth muscle tone findings suggest that the melatonin MT2 receptor is expressed in ASM, and modulates airway smooth muscle tone

the negative sulfate groups in the N-terminus and the positively charged chemokines (Ludeman JP and Stone

mediated activation, which subsequently transactivates purinergic receptors through Gq in intracellular stores

It provided a fundamental understanding of how genetic information is stored and transferred between

Enhance Azobenzene-Based Photopharmacology GPCRs in Cardiology, Endocrinology, and Taste Rap1A Modulates Store-Operated

will likely bring together some of the hottest adhesion GPCR research going on right now and set the tone