Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates crystal deposition and kidney When lowering the severity of the kidney injury, OGR1 KO mice were more prone to develop crystalline OGR1 deficiency, however, increases crystal deposition leading to impaired kidney function. for the pathophysiology of oxalate kidney stones or other crystallopathies." disease , hyperoxaluria , inflammation , kidney stones Source Contribute to the GPCR News Coming soon

Jinqiancao granules are a traditional Chinese medicine used to treat kidney stones and this medicine

Immunology Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney 28, 2023 Abstract " Background and purpose: Activated fibroblasts deposit fibrotic matrix in chronic kidney Here, we set out to establish a transcriptional profile that identifies activated kidney fibroblasts Correlative histology was performed in human kidney tissue. Tags Adenosine receptor , Fibroblast , Fibrosis , GPCR , Kidney , Tcf21 .

News < GPCRs in Oncology and Immunology Noval insights and therapeutic strategies for tumor-induced kidney

Pluznick discovered that olfactory receptors in mice are also expressed in their kidneys and blood vessels This work contributes to a better understanding of how the kidney helps maintain homeostasis in humans

Rezwan Parag Identification of Differentially Expressed Gpr116 (Adgrf5) Transcript Variants in Mouse Kidney We detected and aligned three Adgrf5 exons that undergo differential expression in the kidney: exons These data demonstrate that Adgrf5 transcript variants are cell-specific in the kidney. Moreover, the complete repertoire of aGPCRs expressed in the kidney is undefined. These results reveal the complete set of aGPCRs expressed in the murine kidney.

GPR110 is also highly expressed in the kidney, however, little is known about the function of this receptor To extend our understanding of the role of GPR110 signaling in kidney, we evaluated the urine albumin provide the molecular basis for the renal phenotype, we analyzed in parallel differential expression of kidney

Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney

could promote coronavirus porcine epidemic diarrhea virus (PEDV) infection in African green monkey kidney epithelial cells (Vero) and Lilly Laboratories cell-porcine kidney 1 epithelial cells (LLC-PK1). that G protein-coupled receptor (GPCR)-phospholipase C (PLC)-inositol trisphosphate receptor (IP3R)-store-operated trisphosphate receptor (IP3R)-SOC signaling was activated by IL-8, releasing the intracellular Ca2+ stores

In 1983, he joined the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the

Jurgen Wess’s lab at the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) - NIH,

Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc

, increased Gpr176 expression was also observed in other organs affected by fibrosis, including the kidney

differentiation, altered mesenchymal cell synthetic function, and reduced lung TGFβ2 deposition, as well as kidney

The role of GPR56 in the kidneys has been understudied. A recent study demonstrated that GPR56 in the glomerular endothelial cells promoted diabetic kidney disease physiology, I systematically characterized the function of sodium/hydrogen exchanger 3 in the intestine and kidneys

Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney

biomarker discovery for inflammatory bowel disease and small molecules drug discovery for polycystic kidney

Hailey Steichen Identification of Differentially Expressed Gpr116 (Adgrf5) Transcript Variants in Mouse Kidney

Trauelsen , Muthulakshmi Ponniah , Marc Severin , Albin Sandelin , Marie Kveiborg , Thue W Schwartz , Stine

Craig Malbon at SUNY Stony Brook studying the role of G-protein coupled receptors (GPCRs) and their regulators