OR function has been implicated in myelogenous leukemia where OR2AT4 activation leads to reduced proliferation and enhanced apoptosis of acute myeloid leukemia cells (S Manteniotis et al. 2016).

BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia

of P2Y12 receptor in cancer development Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia

News < GPCRs in Oncology and Immunology Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia Published date June 14, 2024 Abstract " Purpose: The inherent genetic heterogeneity of acute myeloid leukemia performed targeted sequencing, high-throughput drug screening, and single-cell genomic profiling on leukemia high accuracy in predicting sensitivity to some drug classes, such as MEK inhibitors for RAS-mutated leukemia

BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia Published date July 1, 2024 Abstract "Imatinib (IM), a breakthrough in chronic myeloid leukemia (CML Thapliyal, Shailendra Handu Tags RNA-seq , S1PR , SphK1 , herbal compounds , imatinib resistance , leukemia

Oncology and Immunology Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia , 2022 Abstract Blocked cellular differentiation is a critical pathologic hallmark of acute myeloid leukemia