September 2022 Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs be an important factor for survival in four other cancers (clear renal cell carcinoma: p < 0.001, lung ; (d) RGS20 was found to be significantly associated with some tumor-related signaling pathways and long

October 2022 "Systolic heart failure (HF) is a chronic clinical syndrome characterized by the reduction in cardiac function and still remains the disease with the highest mortality worldwide. Despite considerable advances in pharmacological treatment, HF represents a severe clinical and social burden. Chronic human HF is characterized by several important neurohormonal perturbations, emanating from both the autonomic nervous system and the adrenal glands. Circulating catecholamines (norepinephrine and epinephrine) and aldosterone elevations are among the salient alterations that confer significant hormonal burden on the already compromised function of the failing heart. This is why sympatholytic treatments (such as β-blockers) and renin-angiotensin system inhibitors or mineralocorticoid receptor antagonists, which block the effects of angiotensin II (AngII) and aldosterone on the failing heart, are part of the mainstay HF pharmacotherapy presently. The adrenal gland plays an important role in the modulation of cardiac neurohormonal stress because it is the source of almost all aldosterone, of all epinephrine, and of a significant amount of norepinephrine reaching the failing myocardium from the blood circulation. Synthesis and release of these hormones in the adrenals is tightly regulated by adrenal G protein-coupled receptors (GPCRs), such as adrenergic receptors and AngII receptors. In this review, we discuss important aspects of adrenal GPCR signaling and regulation, as they pertain to modulation of cardiac function in the context of chronic HF, by focusing on the 2 best studied adrenal GPCR types in that context, adrenergic receptors and AngII receptors (AT 1 Rs). Particular emphasis is given to findings from the past decade and a half that highlight the emerging roles of the GPCR-kinases and the β-arrestins in the adrenals, 2 protein families that regulate the signaling and functioning of GPCRs in all tissues, including the myocardium and the adrenal gland." Read more at the source #DrGPCR #GPCR #IndustryNews

November 2021 Twist Bioscience Launches Revelar Biotherapeutics to Develop and Commercialize Novel COVID

< GPCR News < GPCRs in Oncology and Immunology Severity of neurological long-COVID symptoms correlates The pathogenesis of Long-COVID is currently under heavy scrutiny and existing data on the role of auto-immune moderate SARS-CoV-2 infection up to 12 months prior to enrollment with (n = 72) or without (n = 58) Long-COVID Results: The prevalence and concentrations of evaluated autoantibodes were significantly higher in Long-COVID significantly higher number of patients with simultaneous detection of more than one autoantibody in Long-COVID

News < GPCRs in Oncology and Immunology Observational Study of Repeat Immunoadsorption (RIA) in Post-COVID This observational study aims to evaluate the efficacy of IA in patients with post-COVID-19 ME/CFS. Due to the urgency of finding therapies for post-COVID-Syndrome (PCS), we report here the interim results , Myalgic Encephalomyelitis/Chronic Fatigue Syndrome , SF-36 , autoantibodies , immunoadsorption , long COVID , physical function , post-COVID syndrome Source Contribute to the GPCR News Coming soon Become

Oncology and Immunology Increased protease-activated receptor 1 autoantibodies are associated with severe COVID -19 Published date December 27, 2022 Abstract In patients with severe #COVID19 , increased levels of endothelial cells and platelets, and thus might contribute to the pathogenesis of microthrombosis in COVID Hoyer , Andreas Glück , Martina Guggeis , Alexander Ossysek , Andre Küller , Derk Frank , Christoph Lange