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with membrane-bound receptor C3aR to regulate innate immune cell function and outcome of bacterial infection is imperative that we revisit previous studies regarding the role of C3aR in controlling bacterial infections specific roles of C3aR in driving cell type–specific and tissue specific responses during bacterial infections and emphasize the contribution of the C3a–C3aR axis in regulating host resistance to bacterial infection

September 2022 Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs to be an important factor for survival in four other cancers (clear renal cell carcinoma: p < 0.001, lung ; (d) RGS20 was found to be significantly associated with some tumor-related signaling pathways and long

Juan Jose Fung, Principal Scientist, at GPCR Therapeutics.

October 2022 "Systolic heart failure (HF) is a chronic clinical syndrome characterized by the reduction in cardiac function and still remains the disease with the highest mortality worldwide. Despite considerable advances in pharmacological treatment, HF represents a severe clinical and social burden. Chronic human HF is characterized by several important neurohormonal perturbations, emanating from both the autonomic nervous system and the adrenal glands. Circulating catecholamines (norepinephrine and epinephrine) and aldosterone elevations are among the salient alterations that confer significant hormonal burden on the already compromised function of the failing heart. This is why sympatholytic treatments (such as β-blockers) and renin-angiotensin system inhibitors or mineralocorticoid receptor antagonists, which block the effects of angiotensin II (AngII) and aldosterone on the failing heart, are part of the mainstay HF pharmacotherapy presently. The adrenal gland plays an important role in the modulation of cardiac neurohormonal stress because it is the source of almost all aldosterone, of all epinephrine, and of a significant amount of norepinephrine reaching the failing myocardium from the blood circulation. Synthesis and release of these hormones in the adrenals is tightly regulated by adrenal G protein-coupled receptors (GPCRs), such as adrenergic receptors and AngII receptors. In this review, we discuss important aspects of adrenal GPCR signaling and regulation, as they pertain to modulation of cardiac function in the context of chronic HF, by focusing on the 2 best studied adrenal GPCR types in that context, adrenergic receptors and AngII receptors (AT 1 Rs). Particular emphasis is given to findings from the past decade and a half that highlight the emerging roles of the GPCR-kinases and the β-arrestins in the adrenals, 2 protein families that regulate the signaling and functioning of GPCRs in all tissues, including the myocardium and the adrenal gland." Read more at the source #DrGPCR #GPCR #IndustryNews

through binding the EBI2 (GPR183) to stimulate effective adaptive immunity and antibody production during infection Aberrant EBI2 signaling is implicated in inflammatory bowel disease, sclerosis, and infectious disease

immunothrombosis has become more relevant than ever, as a majority of COVID-19 patients display thrombi in the lung Furthermore, NETs can be found in the lung and other tissues and are associated with an increased mortality cytokine storm that potently activates neutrophils and leads to massive neutrophil infiltration into the lung

and Receptor Activation in Chemokine–Chemokine Receptor Complexes Industry News Mavorixafor reduces infection patients with WHIM syndrome Bristol Myers Squibb’s Investigational LPA1 Antagonist Reduces the Rate of Lung

Pulmonary Fibrosis "Idiopathic pulmonary fibrosis (IPF) is a disease characterized by irreversible lung We demonstrate that OGR1 protein expression is significantly reduced in lung tissue from patients with

intestine, the human G protein-coupled receptor (GPCR) GPR35 is involved in oncogenic signaling, bacterial infections Our results reveal that the extended N-terminus of the long isoform limits G protein activation yet elevates constitutive G13 activation, while an additional cysteine contributed by the extended N-terminus of the long and allow for mechanism-based therapies against, for example, inflammatory bowel disease or bacterial infections

of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans Comparison of infectious $4.6 Million in Milestone Payments from Centessa Pharmaceuticals CB1 receptor inverse agonist improves lung

In a LPS-induced lung inflammation model in mice, ACT-660602 led to significantly reduced recruitment

TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum

human islets AT2 receptor agonist LP2 restores respiratory function in a rat model of bleomycin-induced lung G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung

defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection "Healthy skin maintains a diverse microbiome and a potent immune system to fight off infections. Defensins and Mrgpra2 were critical for combating S. aureus infections and the formation of neutrophil

mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of in vivo infection DC to the salivary gland and the frequency of reactivation events from latently-infected tissue explants Following intranasal infection with MCMV M33ΔC38, the absence of M33 CREB Gq/11-dependent signalling correlated with reduced mobilisation of lytically-infected DC to draining lymph node high endothelial In contrast, M33ΔC38-infected DC within the vascular compartment extravasated to the salivary glands

analyses, have indicated that OR genes are also expressed in non-olfactory tissues including the testis, lung In non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and migration in long-term stimulus experiments (Kalbe B. et al. 2017).

host-directed CRISPR-Cas9 screen and identified 361 genes that modify macrophage susceptibility to Hc infection We showed that C3aR localizes to the early phagosome during Hc infection where it coordinates the formation

Immunology Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung

wide range of immune responses in different physiologic and pathologic states such as tissue repair, infection

briefly discuss the therapeutic targeting of vGPCRs as future treatment of acute and chronic herpesvirus infections

been developed, with a focus on small molecules and monoclonal antibodies for the treatment of cancer, infections

August 2022 "Host response to infection involves the activation of the complement system leading to the

from central nervous system injuries, in several chronic, peripheral inflammatory entities and in some infective

DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection Announces Positive Phase 3 Results Showing Mavorixafor Reduced the Rate, Severity, and Duration of Infections

Jiangsu Nhwa Pharmaceutical "Submission supported by data from a Phase 3 bridging study of oliceridine injection Products Administration (NMPA) has accepted submission of a New Drug Application (NDA) for oliceridine injection Pharmaceutical, and follows completion by Nhwa of a Phase 3 bridging trial for OLINVYK (oliceridine) injection

disorder GPCRs in Oncology and Immunology Regulator of G protein signaling protein 6 alleviates acute lung

DRD1 is exempt from TGFβ-mediated antifibrotic GPCR landscape tampering in lung fibroblasts. βHB inhibits

October 2022 "Numerous physiological processes in insects are tightly regulated by neuropeptides and Neuropeptides and their receptors have been documented in many hemipteran insects, but the differences