October 2022 Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable To this end, we comprehensively analyzed the potential role of ADGRA1 in the neurobehaviors of mice by We found that Adgra1-/- male but not female mice exhibited elevated anxiety levels in the open field, and spine density as evidenced by elevated expression levels of SYN and PSD95 in amygdalae of male mice activated when compared to wt male mice.

The resulting homozygous hPTH1R-KI (humanized) mice were healthy over at least 10 generations and showed The initial evaluation of these mice and their potential utility for predicting behavior of PTH analogues

September 2022 Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following

pharmacology is derived from rodent models, but most of this preclinical research has only focused on male mice head-twitch behavior (HTR) - a mouse behavioral proxy of human psychedelic potential - in male and female mice DOI elicited more HTR in female as compared to male C57BL/6J mice, a sex-specific exacerbated behavior Volinanserin (or M100907) - a 5-HT2AR antagonist - fully prevented DOI-induced HTR in male and female C57BL/6J mice monophosphate (IP1) in the frontal cortex upon DOI administration showed no sex-related effect in C57BL/6J mice

cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice retinal GPR3 expression and its possible involvement in axonal regeneration after retinal injury in mice Surprisingly, RGCs in GPR3 knockout mice were vulnerable to neural death during aging without affecting Evaluation of the effect of GPR3 on axonal regeneration using GPR3 knockout mice revealed that GPR3 in expression in RGCs helps maintain neuronal survival and accelerates axonal regeneration after ONC in mice

However, Gpr3-deficient mice display several adverse phenotypes, including elevated anxiety-like behavior In contrast to Gpr3-deficient mice, G protein-biased GPR3 mice do not display elevated anxiety levels suggest a protective glial response that may limit amyloid plaque development in G protein-biased GPR3 AD mice

of C265 augments β2AR protein kinase A signaling, enables β2AR nitric oxide (NO) signaling, renders mice resistant to bronchoconstriction, and protects mice from allergen-induced asthma."

Taking advantage of a striking deficit of both NPS receptor (NPSR1) and NPS precursor knockout mice in we demonstrate that intra-PVT injections of NPS can rescue the phenotype in NPS precursor knockout mice salience of otherwise low-intensity stimuli, while intra-PVT injections of NPSR1 antagonist in wild type mice

tissues of active ulcerative colitis (UC) patients and dextran sulfate sodium (DSS)-induced colitis mice GPR84+ macrophages are significantly increased in the colonic mucosa of both the UC patients and the mice Consistently, GPR84-/- mice are resistant to the development of colitis induced by DSS.

uniquely rod phototransduction, we generated transgenic rods expressing Gγ1, Gγc, or Gγ11 in Gγ1-deficient mice However, Gαt1 translocation in Gγ11 transgenic mice occurred at significantly dimmer background light recordings revealed gradual response recovery in moderate background illumination in Gγ11 transgenic mice

Methods: To address this question, we studied mice that express a Gs-coupled designer G protein-coupled Results: Acute stimulation of GsD signaling in SKM impaired glucose tolerance in lean and obese mice Clenbuterol injection improved glucose tolerance by increasing insulin secretion in lean mice.

the critical acaricides/insecticides for effective control of pest infestation of Varroa destructor mite

Studies of GPR21 knock-out mice indicated that GPR21 may be involved in promoting macrophage migration

Azodopa increases the overall neural activity in the cortex of anesthetized mice and displays illumination-dependent

Experimental approach: We used a series of behavioural assays to evaluate the acute responses of mice

In a LPS-induced lung inflammation model in mice, ACT-660602 led to significantly reduced recruitment

Their research reveals how VU0486846 reduces neurogliosis in female Alzheimer's mice. Dr. receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer's mice

mouse expressing a non-cleavable GPR116 mutant phenocopies the pulmonary phenotype of GPR116 knock-out mice

GPCR Activation and Signaling Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility Cannabinoid tolerance in S426A/S430A x beta-arrestin 2 knock-out double mutant mice.

Finally, inhibition of Gq-GPCR coupling in mice enhanced the antinociceptive effects of morphine.

TRPM3's best understood function is its role as a peripheral noxious heat sensor in mice.

effect of CCL25 on the development of SACC in vivo was examined by a xenograft tumor model in nude mice

In adult mice, intraperitoneal ketanserin injection increased basal TrkB phosphorylation in the frontal

and Pina M Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic cells in mice Novel C-X-C Chemokine Receptor 4 Antagonist and Mobilizer of Hematopoietic Stem/Progenitor Cells, in Mice

protein (YAP) signaling in endothelial cells, which was evidenced by the attenuation of organ fibrosis in mice

inhibition of cell proliferation, colony formation, migration, invasion and xenograft tumor growth in nude mice

formation by PDAC cells and suppessed the growth of MiaPaCa-2 cells xenografted into the flank of nude mice

ARRB1 alleviates tauopathy and rescues impaired synaptic plasticity and cognitive impairments in PS19 mice