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GPR21 couples to the Gq family of G proteins and is expressed in macrophages. Studies of GPR21 knock-out mice indicated that GPR21 may be involved in promoting macrophage migration The aim of this study was to evaluate the role of GPR21 in human macrophages, analyzing (i) its involvement THP-1 cells were activated and differentiated into either M1 or M2 macrophages. Cell migration was detected by the Boyden chamber migration assay, performed on macrophages derived from

September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model As tumor-associated macrophages (TAMs) serve as major contributors to the immuno-suppressive tumor microenvironment We show that through proper calibration, the model captures the macrophage heterogeneity in the tumor

September 2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation Autophagy deficiency in myeloid cells plays a causal role in eosinophilic CRS (ECRS) via macrophage IL autophagy‐enhancing agent, trehalose, or related sugar compounds, and the underlying mechanism focusing on macrophage Methods We investigated the therapeutic effects of trehalose and saccharin on macrophage IL‐1β production

< GPCR News < GPCRs in Oncology and Immunology Leukotriene B4 receptor 2 governs macrophage migration Macrophages are continuously recruited to tissues during chronic inflammation where they exacerbate or We detected BLT2 expression in bone marrow derived and peritoneal macrophages of mouse models. Transcriptomic analysis of Ltb4r2-/- and WT macrophages suggested a role for BLT2 in macrophage migration Collectively, our results demonstrate that BLT2 mediates macrophage migration during inflammation, which

< GPCR News < GPCRs in Oncology and Immunology Deletion of macrophage Gpr101 disrupts their phenotype Herein, we investigated the endogenous role of this pro-resolving receptor in modulating macrophage biology Peritoneal macrophages obtained from naïve MacGpr101KO mice displayed a marked shift in the expression The alterations in macrophage phenotype observed in Gpr101 deficient macrophages were maintained following Together these findings identify Gpr101 as a novel regulator of both macrophage phenotype and function

inflammation and tissue injury via prosaposin-GPR37 signaling Published date July 11, 2023 Abstract "Macrophages We report that efferocyte-derived EVs express prosaposin, which binds to macrophage GPR37 to increase efferocyte-derived EVs in a murine model of atherosclerosis is associated with an increase in lesional macrophage Thus, we establish a critical role for efferocyte-derived vesicular mediators in increasing macrophage Subramanian Tags CP: Immunology , GPCR , atherosclerosis , efferocytosis , inflammation resolution , macrophage