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< GPCR News < GPCRs in Oncology and Immunology Leukotriene B4 receptor 2 governs macrophage migration Macrophages are continuously recruited to tissues during chronic inflammation where they exacerbate or We detected BLT2 expression in bone marrow derived and peritoneal macrophages of mouse models. Transcriptomic analysis of Ltb4r2-/- and WT macrophages suggested a role for BLT2 in macrophage migration Collectively, our results demonstrate that BLT2 mediates macrophage migration during inflammation, which

< GPCR News < GPCRs in Oncology and Immunology Deletion of macrophage Gpr101 disrupts their phenotype Herein, we investigated the endogenous role of this pro-resolving receptor in modulating macrophage biology Peritoneal macrophages obtained from naïve MacGpr101KO mice displayed a marked shift in the expression The alterations in macrophage phenotype observed in Gpr101 deficient macrophages were maintained following Together these findings identify Gpr101 as a novel regulator of both macrophage phenotype and function

inflammation and tissue injury via prosaposin-GPR37 signaling Published date July 11, 2023 Abstract "Macrophages We report that efferocyte-derived EVs express prosaposin, which binds to macrophage GPR37 to increase efferocyte-derived EVs in a murine model of atherosclerosis is associated with an increase in lesional macrophage Thus, we establish a critical role for efferocyte-derived vesicular mediators in increasing macrophage Subramanian Tags CP: Immunology , GPCR , atherosclerosis , efferocytosis , inflammation resolution , macrophage

metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages treatment with β-hydroxybutyrate increased gene expression of GPR109A, CD86, IL1B and NOS2 in U937-derived macrophages transiently silenced, the mRNA expression and secretion of IL-1β, IL-6 and TNF-α were impaired in M1 macrophages Finally, the secretome from siGPR109A M1 macrophages reduced the gene and protein expression of COL1A1 IBD , Metabolite-sensing GPCRs , Metabolomic alterations , Microbiota dysbiosis , Pro-inflammatory macrophages

adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages (LUAD) patients, closely related to their prognosis and positively correlated with tumor-associated macrophages Tags A2aR , Lung adenocarcinoma , Migration , Polarization , Targeted therapy , Tumor-associated macrophages

In addition, GSEA showed that GPR37 was positively correlated to the positive regulation of macrophage expression was significantly associated with the infiltration of T cells, CD8 T cell, eosinophils, macrophages In addition, high GPR37 expression was positively correlated with increased infiltration of M2 macrophages Degui Liao , Miaoling Lai , Huaidong Peng , Yanbin Ke , Zhaotao Wang , Yezhong Wang Tags GPR37 , M2 macrophages

profile GPCR transcripts in white blood cells (WBCs)-B, CD4, CD8, NK, and dendritic cells; monocytes, and macrophage-like monocytes treated with granulocyte-macrophage colony-stimulating factor-as well as platelets.

For in vitro studies, microglia and peritoneal macrophages were isolated from adult WT mice and treated In the isolated microglia and peritoneal macrophages, ethanol also exacerbated the LPS-induced expression Yoo Sun Kim , Hee-Yong Kim Tags Adenylyl cyclase , Cytokines , GPCR , Gavage , Lipopolysaccharide , Macrophages

In addition, he explored the role of the host membrane in the entry of intracellular pathogens into macrophages

chemokines are often elevated in disease settings, where the largest group of CC-chemokines are the macrophage

fibroblasts abundantly expressed Gpr176 compared to alveolar epithelial cells, endothelial cells, and macrophages

VSMCs treated with BC-CM displayed enhanced pro-inflammatory phenotype and higher adherent with macrophages

activation of the immune system and a higher production of pro-inflammatory cytokines by T cells and macrophages

myeloid-lineage cells, including neutrophils (CD11b + Gr1+), monocytes (CD11b + Gr1-Ly6C+ and CD11b + Gr1-Ly6C-), macrophages

Nitric acid (NO) inhibition was tested on the macrophage cell line RAW264.7.

addition, RGS6 overexpression decreased ROS production as well as proinflammatory factor transcription in macrophages