September 2022 GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response Functional studies showed that GASP1 knockout significantly suppressed malignant properties of breast stimulated GASP1 expression by activating the PI3K/AKT pathway, forming a vicious cycle propelling the malignant Collectively, this study demonstrates that GASP1 enhances malignant behaviors of breast cancer cells

September 2022 CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma However, the effect of CCR9 on salivary adenoid cystic carcinoma (SACC) malignant behavior remains unknown This study aimed to investigate the specific molecular mechanism by which CCR9/CCL25 modulates malignant

Additionally, CXCR4 is expressed by tumor cells in blood malignancies and solid tumors."

target " Purpose: Beta 2-Adrenergic Receptor (β2-AR) is significantly overexpressed in various types of malignancies

chemicals, hormones, cytokines, and, recently, gene editing techniques, have been tested to reduce the malignancy

(PAR), a subgroup of GPCRs, form a family of four members (PAR1-4) centrally involved in epithelial malignancies

transport, tooth eruption, bone formation and bone remodeling, and causes hypercalcemia in patients with malignancy

Glioma is the most common adult malignant brain tumor and requires novel therapeutic strategies to improve

GTPase activity and result in constitutive signaling, as occurs with the αqQ209L mutation in uveal melanoma

in situ visualization and quantification of SST2/SST5 dimerization in rat GH3 as well as in human melanoma

immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma

responses and a comprehensive understanding of the role of the chemokine receptor system in different malignancies

GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment.

challenging because most receptors lack structural features in their soluble domains to facilitate image alignment

The pipeline compiles and aligns sequences from public sources, reconstructs the phylogeny, prunes rogue

existing experimental data in the literature as constraints, we pinpointed conserved motifs to entirely re-align

The predicted models were then aligned with the experimentally solved structures and evaluated by the

dose- and frequency-dependent manner, and triggered the formation of cell condensations that developed aligned

GPCR molecular dynamics forecasting using recurrent neural networks A method for multiple-sequence-alignment-free

Furthermore, when an alignment analysis of the Stalk peptide of the aGPCR family was performed highlighted

major bottleneck requiring extensive experimental datasets and in vivo validation which does not always align

comparing the CKRs structures complexes, the disulfide bridges formed between the N-loop and the β3-strand align