< GPCR News < GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in microenvironment Published date December 23, 2022 Abstract Due to its high metastatic potential, malignant melanoma In melanoma as well as in other cancers, acidification of the tumor microenvironment (= TME, inverse Results indicate that GPR4 is involved in the migration of melanoma cells, especially in the tumor periphery Haubner , Joachim Wegener , Stephan Schreml Tags Boyden chamber , ECIS , GPR4 , impedance , malignant melanoma

Program < Back to schedule Developing a PROTAC to Degrade the Constitutively Active Onco-GPCR in Uveal Melanoma

immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma Qin , Yanwen Yang , Chuanyuan Wei , Jianying Gu Tags G protein-coupled receptors , Immunotherapy , Melanoma

Chan Chae Tags GPR143 , HRS , MVB , breast cancer , exosomal protein sorting , exosome biogenesis , melanoma

model of a G-protein coupled receptor signaling network that is mutated in almost all cases of uveal melanoma

discovered, along with Yu Chen and Ping Chi , that a mutant of CYSLTR2 is a driver oncogene in uveal melanoma

November 3rd / 4:20 PM Developing a PROTAC to Degrade the Constitutively Active Onco-GPCR in Uveal Melanoma

the GPCR side of the lab, which led to the discovery of potential tumor suppressors and oncogenes in melanoma