synaptic events, exocytosis, transcriptional regulation, and more, PKA signaling regulates cellular metabolism afferent and peripheral efferent signals that link specific neural cell populations to the regulation of metabolic Mouse models have provided invaluable information on the roles for PKA subunits in brain and key metabolic Variants identified in PKA subunit genes cause Cushing syndrome that is characterized by metabolic dysregulation

October 2022 "Background: Uncoupling proteins (UCPs) are unpaired electron carriers that uncouple oxygen intake by the electron transport chain from ATP production in the inner membrane of the mitochondria. The physiological activities of UCPs have been hotly contested, and the involvement of UCPs in the pathogenesis and progression of diabetes mellitus is among the greatest concerns. UCPs are hypothesised to be triggered by superoxide and then reduce mitochondrial free radical production, potentially protecting diabetes mellitus patients who are experiencing oxidative stress. Objectives: The objectives of the study are to find out the newest ways to treat diabetes mellitus through protein uncoupling." Read more at the source #DrGPCR #GPCR #IndustryNews

October 2022 Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism Whether and how RH affects responses within metabolically important peripheral organs to counterregulatory Objective: To study the effects of RH on metabolic pathways associated with glucose counterregulation G-protein coupled receptors (GPCRs), their inhibitory regulators and downstream enzymes catalyzing glycogen metabolism

GPCR Podcast << Back to podcast list Re-cap of Endocrine Metabolic GPCR 2024 with the Organizers About Aylin Hanyaloglu on the web LinkedIn Endocrine Metabolic GPCRs Researchgate Twitter Imperial College Her current research focuses on how metabolic GPCRs cross-talk and interact to regulate appetite and bone metabolism." Caroline Gorvin on the web University of Birmingham Endocrine Metabolic GPCRs Society of Endocrinology

Oncology and Immunology GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism GPR37 protects cancer cells from ferroptosis by upregulating SCD1 expression, thereby modulating lipid metabolism Mechanistic studies have shown that GPR37 modulates lipid metabolism in tumor cells by promoting SCD1 Li, Zhen Xiang, Yixiu Wang, Ti Zhang, Weiqi Xu, Lu Wang, Anrong Mao Tags Ferroptosis , GPR37 , Lipid metabolism

Pharmacological and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic in exploiting GPCR biased signaling to design/develop new pharmacotherapeutics to treat reward- and metabolism-based is to better understand the underlying mechanisms of food reward and its downstream dysregulation of metabolic develop novel GPCR pharmacotherapies that improve efficacy and minimize side effects for diet-induced metabolic