September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways events ( P  = 0.019) and liver metastasis ( P  = 0.011). At a median follow-up interval of 67.1 months, a significant trend towards reduced distant metastasis-free Besides, high GPER expression was significantly linked to the worse survival in patients with lymph node metastasis Transcriptome-based bioinformatics analysis revealed that GPER was linked to pro-metastatic pathways

organ-specific chemokine receptor, interacts with its exclusive ligand CCL25 to promote tumor proliferation and metastasis

Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell cycle and metastasis

Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell cycle and metastasis

"Research on cancer therapies focuses on processes such as angiogenesis, cell signaling, stemness, metastasis

GPCRs in Oncology and Immunology GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis

However, GRK3’s functions and clinical utility in GAC progression and metastases are unknown. Methods We studied GRK3 expression in normal, primary, and metastatic GAC tissues.

Breast Cancer Cells Does Not Correlate with Kisspeptin Signalling and Migration "Kisspeptin is an anti-metastatic However, controversy remains regarding its role in breast cancer since both pro- and anti-metastatic invasion and MMP-9 expression, leading to the suggestion that hormone receptor status determines the metastatic MDA-MB-231 cells are metastatic when implanted in mice while BT-20 are not and remain epithelial-like data shows that, in TNBC, it is not universally true that kisspeptin/KISS1R stimulate migration or pro-metastatic

survival signals, establish and maintain an immunosuppressive tumor microenvironment, and facilitate metastatic

first patient dosed with DT-9081 in phase I clinical study in patients with advanced, recurrent or metastatic