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8 items found for "miRNA"
- Deciphering a GPCR-lncRNA-miRNA Nexus: Identification of an Aberrant Therapeutic Target in Ovarian Cancer
< GPCR News < GPCRs in Oncology and Immunology Deciphering a GPCR-lncRNA-miRNA Nexus: Identification In this study, we elucidate the tripartite interaction between LPA-signaling, UCA1, and let-7 miRNAs Mechanistically, UCA1 sequesters let-7 miRNAs, effectively neutralizing their tumor-suppressive functions More significantly, intratumoral delivery of UCA1-specific siRNAs inhibits the growth of cisplatin-refractory Isidoro , Yong Sang Song , Danny N Dhanasekaran Tags GPCR , High Grade Serous Ovarian Carcinoma , Let-7 miRNAs
- Comparative analysis of the occupancy of Histone H3 Lysine 4 methylation in the cells treated with TGFβ and Interferonγ
the TGFβ and IFNγ dataset revealed association of genes with different biological processes such as miRNA-mediated
- miR-19a may function as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6/GPCRs/PKC in a Chinese population
Zhang , Jiayan Fan , Hongyan Gao , Xinyu Xia , Wei Wu , Yuyuan Shi Tags GPCR , GRK6 , OSCC , PKC , miRNA
- Exploration of prognostic and treatment markers in hepatocellular carcinoma via GPCR-related genes analysis
; protein-protein interaction (PPI) mechanisms were explored; hub genes and micro ribonucleic acid (miRNA
- GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression
analysis of mouse lungs with induced fibrosis, eight GPCRs were identified, showing a >2-fold increase in mRNA unaffected by TGFβ1 stimulation in rat renal fibroblast NRK-49 cells, whereas knockdown of Gpr176 by siRNA
- NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
In this study, we show that the upregulation of NPFFR2 mRNA was associated with poor overall survival Using the siRNA-mediated knockdown approach, we showed that the stimulatory effect of NPFF on MMP-9 expression
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
shown by using the SFK inhibitors dasatinib, saracatinib, the preferential YES1 inhibitor CH6953755, siRNA-mediated
- GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment
Lastly, we use siRNA and CRISPRi to demonstrate the critical role of ATF4 suppression via GPR68 for GBM