revealed that in the interactome of VLGR1, molecules are enriched that are associated with both the ER and mitochondria , as well as mitochondria-associated ER membranes (MAMs), a compartment at the contact sites of both resulted in alterations in the MAM architecture and in the dysregulation of the Ca2+ transient from ER to mitochondria

September 2022 GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting We recently have shown that fluorescently labeled Hst1 (F-Hst1) targets and activates mitochondria, presenting respiration and Na+/K+-ATPase activity on the uptake, mitochondria-targeting and -activating properties Only the inhibitor of CME and KD of S2R/TMEM97 significantly compromised the mitochondria-targeting of its mitochondria-activating property."

uncouple oxygen intake by the electron transport chain from ATP production in the inner membrane of the mitochondria UCPs are hypothesised to be triggered by superoxide and then reduce mitochondrial free radical production

transmembrane non-GPCR protein expressed mainly in the endoplasmic reticulum membrane associated with mitochondria

GPCRs have also been identified within the mitochondria. Initial investigations revealed the positioning of the cannabinoid CB1 receptor on the outer mitochondrial membrane of skeletal and myocardial cells, where stimulation of mitochondrial CB1 receptors by lipophilic Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration

model for ovarian cancer prognosis GprC of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria

neurons to suppress feeding The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria

Inhibition of this pathway rescues the alterations in PC morphology and mitochondrial dysfunction. dysfunction may be required for the development of pathoetiological phenotypes observed in sPD like mitochondrial

complex (involved in nutrient stress sensing), glycosylation enzymes, protein degradation machinery, mitochondrial

G-protein-coupled receptor is an ambient glucose sensor in skeletal muscle that regulates NAD homeostasis and mitochondrial

Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior Acetate mitigates cardiac mitochondrial

Islet Physiology TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial