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Here we used zebrafish and mouse models to probe the role of BLT2 in macrophage function during inflammation We detected BLT2 expression in bone marrow derived and peritoneal macrophages of mouse models. Raghavendra G Mirmira Tags G-protein coupled receptor (GPCR) , Macrophage , inflammation , metabolism , mouse

Oncology and Immunology The GPCR adaptor protein Norbin controls the trafficking of C5aR1 and CXCR4 in mouse Norbin suppresses C5aR1 signalling in mouse neutrophils by limiting the C5a-stimulated membrane translocation

Methods: We studied human and mouse PMN signaling elicited by mtDAMPs (GPCR surface expression; protein Predicted rescue therapies were assessed in cell systems and mouse injury-dependent pneumonia models. Either GRK2 or HDAC inhibition prevented loss of mouse lung bacterial clearance, but only the combination

behavioral assays, autoradiography, stereotaxic surgeries, electroencephalography, immunohistochemistry, mouse

of GPR56 in the collecting duct, we generated a collecting duct-specific GPR56 knockout (GPR56CD-KO) mouse This mouse model will be useful to delineate the collecting duct-specific role of GPR56 for renal function During my graduate studies, using various transgenic mouse models and expertise in intestinal and renal We found an interaction between BAI3 and MAGI3 in mouse brain lysates. This study aimed to understand the effects of GPR110 on mouse behaviors in relation to neurodevelopmental

His laboratory uses knock-out and transgenic mouse models, along with different cell culture systems,

characterized the role of RGS4 and RGS5 in airway hyperresponsiveness and lung fibrosis in acute and chronic mouse

steroidogenesis in regulating sexual determination and adrenal and gonadal development using genetic mouse

Genetic mouse models of CRC coupled with Gpr176-deficiency are investigated, and in vivo and in vitro

Rashed Rezwan Parag Identification of Differentially Expressed Gpr116 (Adgrf5) Transcript Variants in Mouse To test this, an LFS mouse model (germline Tp53 deletion) with a second floxed allele under the control Preliminary findings indicate that the simultaneous loss of Bai3 and Tp53 expression in our mouse model A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development Two major types of mRNAs were identified in human/mouse brain, those with a start codon in exon 2 encoding

that GPR50 could protect against breast cancer development and decrease tumor growth in a xenograft mouse

laboratory is to understand the physiological consequences of NMDA receptor deficiency using genetic mouse

Importantly, 8GL alone or in combination with an mTOR inhibitor remarkably impaired tumor growth and extended mouse

These drugs were shown to be very effective to rescue the cell death observed in a mouse model of Huntington

enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse

enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse

enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse

critical expertise, and rigorous approaches to examine PAR1 function using human cultured cells and mouse

enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse

In gene expression analysis of mouse lungs with induced fibrosis, eight GPCRs were identified, showing

investigated the endogenous role of this pro-resolving receptor in modulating macrophage biology using a novel mouse

steroidogenesis in regulating sexual determination and adrenal and gonadal development using genetic mouse

., PNAS, 2014) in breast cancer pathogenesis, using mouse models, three-dimensional cell culture and young age and his desire to gain more knowledge about cancer biology led him to transition into using mouse Yamina proposed further exploration of dosage and length of treatment in a mouse model and suggested

protein signaling roles of GPR56/ADGRG1 via the characterization of a non-cleavable point mutant knock-in mouse protein signaling roles of GPR56/ADGRG1 via the characterization of a non-cleavable point mutant knock-in mouse We utilize several genetically modified mouse models to investigate requirements for receptor activator

results provide new insights into the role of Wnt and Gs-signaling in fibrosis and bone formation in a mouse

Experimental approach: RNA sequencing and single cell qRT-PCR were performed on mouse kidneys after unilateral

VIPR2 also exacerbated intraperitoneal proliferation of breast cancer MDA-MB-231 cells in a tumor nude mouse

Title: Linking Proteinase Activated Receptor (PAR) Cleavage to Osteoarthritis (OA) Severity About Amr Mousa Amr Mousa on the web Google Scholar Dr. GPCR Title: Development of a Transgenic Mouse Platform for the Detection of Endogenous G protein Activity