October 2022 Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz However, the underlying molecular mechanism of the enhanced sensitivity or toxicity of amitraz to mutated simulations are employed to explore the implied mechanism of the enhanced sensitivity to amitraz in mutant

September 2022 "Background Cancer driver genes are usually ranked by mutation frequency, which does We hypothesize that driver strength is higher for genes preferentially mutated in patients with few driver mutations overall, because these few mutations should be strong enough to initiate cancer. Strength Index (DSI) and the Normalized Driver Strength Index (NDSI), the latter independent of gene mutation

Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors Because there are many more GPCRs than effectors, mutations in different receptors could perturb signaling We hypothesized that somatic mutations in tumor samples may not be enriched within a single gene but To test this possibility, we systematically aggregated somatic cancer mutations across class A GPCRs Phenotypic characterization suggests these mutations induce perturbation of G protein activation and/

< GPCR News < GPCRs in Oncology and Immunology Functional Assessment of Cancer-Linked Mutations in Sensitive Intolerant and tolerant-control residues that overlap with pathogenic cancer mutations reported in the Identified intolerant residues with reported cancer-linked mutations RGS14-R173C/H and RGS4-K125Q/E126K , including cancer-linked mutations in regulator of G protein signaling (RGS) proteins. We found that 3DMTR more accurately classifies loss-of-function mutations in RGS proteins than other

< GPCR News < GPCRs in Oncology and Immunology Mutation Patterns Predict Drug Sensitivity in Acute Myeloid We also integrated large public datasets to understand the co-occurring mutation patterns and further investigated the mutation profiles in the single cells. to some drug classes, such as MEK inhibitors for RAS-mutated leukemia. It provides a framework for categorizing patients with AML by mutations that enable drug sensitivity

< GPCR News < GPCRs in Oncology and Immunology The Effect of Cancer-Associated Mutations on Ligand Binding In this study, we aimed to investigate the effects of cancer patient-derived 5-HT2C receptor mutations By filtering the sequencing data from the Genomic Data Commons data portal (GDC), we selected 12 mutations These two mutations may disrupt the conserved ionic interaction between E6.30 and R3.50, and thus increase Such mutations may affect serotonin-mediated signaling in tumor cells as well as treatment strategies