October 2022 Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent This signaling axis was required for effective neutrophil-mediated skin immunity and microbiome homeostasis Defensins and Mrgpra2 were critical for combating S. aureus infections and the formation of neutrophil Activation of Mrgpra2 by defensin triggered neutrophil release of IL-1β and CXCL2 which are vital for This study demonstrated the importance of epithelial-neutrophil signaling via the defensin-Mrgpra2 axis

August 2022 GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists "In order to avoid a prolonged pro-inflammatory neutrophil response, signaling chain fatty acid receptor GPR84 as well as formyl peptide receptor 2 (FPR2), receptors expressed in neutrophils In this study, we investigated the effects of GRK2 inhibitors on neutrophil functions induced by GPR84 GRK2 was shown to be expressed in human neutrophils and analysis of subcellular fractions revealed a

Additionally, platelet interactions with neutrophils enhance neutrophil activation and are often crucial In particular, platelets can activate neutrophils to form neutrophil extracellular traps (NETs). This specific neutrophil effector function is characterized by neutrophils expelling chromatin fibres Here, virus infiltration may lead to a cytokine storm that potently activates neutrophils and leads to massive neutrophil infiltration into the lung and NET formation.

Ginsenoside Rg5 allosterically interacts with P2RY12 and ameliorates deep venous thrombosis by counteracting neutrophil

towards CXCR1/2 inhibitors, as these receptors primarily induce the chemotaxis of leukocytes, especially neutrophils

towards CXCR1/2 inhibitors, as these receptors primarily induce the chemotaxis of leukocytes, especially neutrophils

protein-coupled receptor primarily expressed in myeloid cells that constitute the innate immune system, including neutrophils

Adhesion GPCRs The Posttraumatic Increase in the Adhesion of GPCR EMR2/ ADGRE2 to Circulating Neutrophils differentially regulate signaling by the receptors CCR1 and CCR5 Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil

splicing, regulation of RAS by GAPs, neddylation and GPCR ligand binding GPCRs in Oncology and Immunology Neutrophils are itching to specialize A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like

of the pro-inflammatory G protein-coupled receptor GPR84 Function and regulation of GPR84 in human neutrophils Technologies for the discovery of G protein-coupled receptor-targeting biologics Lipid mediators in neutrophil

ovarian cancer nanomedicines: from RNA sequencing data analysis to in vitro validation Signaling by Neutrophil

13 G protein chimeras GPCRs in Oncology and Immunology Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil

G protein-coupled receptor-mediated membrane targeting of PLCγ2 is essential for neutrophil chemotaxis

Larixol is not an inhibitor of Gαi containing G proteins and lacks effect on signaling mediated by human neutrophil

GPCRs in Oncology and Immunology DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil

Oncology and Immunology G Protein-coupled Receptor-mediated Membrane Targeting of PLCγ2 is Essential for Neutrophil

Function and regulation of GPR84 in human neutrophils.

GPCR Activation and Signaling DANGER Signals Activate G -Protein Receptor Kinases Suppressing Neutrophil

Larixol is not an inhibitor of Gαi containing G proteins and lacks effect on signaling mediated by human neutrophil

and Immunology The GPCR adaptor protein Norbin controls the trafficking of C5aR1 and CXCR4 in mouse neutrophils

compounds from butter, known ligands for a variety of class I ORs, induce chemotactic behavior in human neutrophils

Neutrophil Signaling That Challenges Dogmata of G Protein-Coupled Receptor Regulated Functions.