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Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone
We previously showed that ColI(2.3)+/Rs1+ mice, in which Gs-GPCR signaling was hyper-activated in osteoblastic Multiple Wnt ligands were up- or downregulated in different cellular populations, including in non-osteoblastic Sunita Ho, Edward C Hsiao Tags Wnt pathway inhibition , fibrotic bone disease , fibrous dysplasia (FD) , osteoblasts