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404 items found for "physical function"
Posts (280)
- Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5...
However, how these states impact GPCRs biological function and therapeutic targeting remains incompletely
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
involves deliberately altering the DNA sequence of a gene to study the resulting changes in protein function understanding of how drugs interact with different receptor regions and link these interactions to functional This technique has uncovered fundamental aspects of the G protein-coupled receptor (GPCR) function, including Targeted mutagenesis may miss broader functional regions, while random mutagenesis generates extensive play a pivotal role in addressing these obstacles, enhancing our understanding of GPCR structure and function
- Decoding β-Arrestins: from Structure to function
Probing GPCR and β-Arrestin conformational states: methods and implications The formation of functional Nevertheless, the diverse functionalities of various GPCRs, coupled with the fluctuating expression of In addition, the question of whether β-arrestin1 and 2 serve overlapping or distinct functions remains Knockout studies in mice suggest that β-arrestin isoforms possess some level of functional redundancy The observed variations in β-arrestin expression likely impact the composition and function of GPCR-mediated
Other Pages (124)
- Illuminating Functional Selectivity and Allosterism at GPCRs.
Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Illuminating Functional
- Atypical Structure and Function of Typical Chemokine Receptors
Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Atypical Structure and Function
- Unveiling Non-Canonical Functions for Gαq Signaling Pathways
Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Unveiling Non-Canonical Functions