< GPCR News < GPCRs in Oncology and Immunology Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design Published date Previously we identified pleckstrin homology (PH) binding domains within PAR1,2&4 as critical sites for Pc(4-4) binds to the PAR PH binding domain and blocks the association of PH-signal proteins, such as homology (PH) domain , protease-activated receptors (PARs) Source Contribute to the GPCR News Coming

and pathological roles of AGPCRs in the nervous system Uncovering the signaling pathway of the ADGRA homolog To Control Germ Cell Proliferation Willem Berend Post Uncovering the signaling pathway of the ADGRA homolog ADGRA family, sharing the same overall receptor domain structure. Hence, Remo is proteolytically processed, either by the GAIN domain or an alternative protease that cleaved The mammalian Remo homolog ADGRA2/Gpr124 cooperates with other GPCRs of the Frizzled family, and the

< GPCR News < GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in Membrane-bound receptors, such as the proton-sensitive GPCR (pH-GPCR) GPR4, are considered as potential In this study, we investigated the pH-dependent migration of GPR4 wildtype/overexpressing SK-Mel-28 cells Migration of GPR4 overexpressing SK-Mel-28 cells was enhanced in a range of pH 6.5 - pH 7.5 as compared setup, but not at pH 6.5.

A homolog model tool confirmed that GPR176 recruits GNAS intracellularly via its transmembrane helix 3-intracellular loop 2 domain. Ji'ou Gu , Yifei Feng , Kangpeng Jin , Xiaowei Wang , Yueming Sun Tags GPCR , autophagy , growth , homology

Agenda Session VIII * Physiological and pathological roles of AGPCRs in the periphery The CELSR/ADGRC Homolog Flamingo Is Not Autoproteolytically Processed By The GAIN Domain Tobias Langenhan Characterization of role for CD97/ADGRE5 in the induction of allergic airway inflammation Gabriela Aust The CELSR/ADGRC Homolog Flamingo Is Not Autoproteolytically Processed By The GAIN Domain Tobias Langenhan Abstract Only available an endogenous ligand for GPR110, binds to the N-terminal G-protein autoproteolysis-inducing (GAIN) domain

AT2R is interacting with four tumor suppressor proteins, Src homology phosphatase 1, Src homology phosphatase

Both receptors contain PSD-95/Discs-large/ZO-1 homology (PDZ) motifs in their C-terminal tails through , Björn Olde , Kathleen M Caron , L M Fredrik Leeb-Lundberg Tags Breast cancer , GPER , GPR30 , PDZ domain

Structural studies of the CELSR1 extracellular region reveal a compact multidomain module of fourteen domains in a Holo-Adhesion GPCR Fabian Pohl Structural Determinants Of GAIN Domain Autoproteolysis And Cleavage and Its Impact on GAIN Domain Autoproteolysis Douglas Tilley ADGRF5-mediated regulation of cardiac health Jesse Stillwell Next Generation MBD2 inhibitors for Brain Cancer Therapy Lara-Sophie Brodmerkel GAIN Domain Flamingo Is Not Autoproteolytically Processed By The GAIN Domain Yimin Zou ADGRCs in glutamatergic synapse

genes (atypical chemokine receptor 3 (ACKR3), C-C chemokine receptor type 3 (CCR3), CCR7, frizzled homolog receptor 1 (HCAR1), 5-hydroxytryptamine receptor 5A (HTR5A) and nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6 (NLRP6)) was set up.

My initial focus was on creating an automated chimeric homology modeling pipeline for GPCRs and since

My initial focus was on creating an automated chimeric homology modeling pipeline for GPCRs and since

Many of the conceptual advances that stemmed from this work, such as the concept of “functional micro-domains Tom’s lab also pioneered the early use of computational homology modeling, molecular dynamics simulations

Xu et al. identified the mammalian neurokinin 3 receptor (TACR3), a homolog of the G protein-coupled

GPR50 (G protein-coupled receptor 50) is an orphan GPCR that shares the highest sequence homology with

They worked on the interactome of yeast and mammalian Rab5 homologs including identification of Rab5

Kordon Deorphanization Of The Adhesion GPCRs GPR110 and GPR116 Tingzhen Shen Self-Cleavage of GPR110 SEA Domain and Its Impact on GAIN Domain Autoproteolysis Bill Huang Tethered Agonist Dependent ADGRL3 Signaling However, how the ECR communicates with the seven-pass transmembrane domain (7TM) remains elusive, because Tingzhen Shen on the web University of Michigan Self-Cleavage of GPR110 SEA Domain and Its Impact on GAIN Domain Autoproteolysis Bill Huang Abstract Only available for AGPCR 24 Workshop Attendees Authors

Low extracellular pH confers radioresistant tumors to glial cells. Next, A GPI-anchored pH reporter, pHluorin2, was stably expressed in U87 glioblastoma cells to probe

Myeloid Skewing Emmanouil Kyrloglou A single cell GPCR map of thermogenic fat Vasiliki Karagiannakou GAIN Domain Cancer IDC, Helmholtz Centre Munich" Vasiliki Karagiannakou on the web Helmholtz Centre Munich GAIN Domain We are investigating the relevance of GAIN domain dynamics for aGPCR signaling in Drosophila melanogaster Detection of these, as well as 18 other aGPCRs, was confirmed by PCR screening for GAIN/GPS domains on The ADGRB1 promoter is methylated in MB, and this allows for Methyl CpG Binding Domain protein 2 (MBD2

Agenda Session V Structural mechanisms of AGPCR signaling and function Structural Determinants Of GAIN Domain Structural studies of the CELSR1 extracellular region reveal a compact multidomain module of fourteen domains Adhesion G Protein-Coupled Receptors Fabian Pohl Abstract "The GPCR autoproteolysis-inducing (GAIN) domain is a hallmark feature of adhe-sion G-protein coupled receptors (ADGRs), as this extracellular domain We de-termined the crystal structure of the human ADGRB2/BAI2 hormone receptor (HormR) and GAIN domains

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