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to progesterone: a study based on RNA-seq Published date August 8, 2023 Abstract "Background: About one-third of patients with estrogen receptor alpha (ERα)-positive breast cancer have tumors which are progesterone New evidence has shown that progesterone (P4) has an anti-proliferative effect in ERα-positive breast Eduardo , Irene Keller , Nathalie Schuster , Stefan Aebi , Rolf Jaggi Tags Breast cancer cell pools , progesterone response , RNA-seq , CRISPR/Cas9 , estrogen receptor alpha , gene expression , Progesterone receptor

instance, membrane receptor GPR97 is able to sense glucocorticoid to mediate its rapid actions, the progesterone

< GPCR News < GPCRs in Oncology and Immunology Ultrasensitive dose-response for asbestos cancer risk In contrast, a linear no-threshold (LNT) dose-response relationship is expected for damage that accumulates both, rendering ambiguous expectations concerning the nature of model-implied shape of the low-dose response somatic mutations) of the most efficient pathway to any type of cancer in any reparable tissue (Dose-Response

Immunology Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses This was linked with an increased inflammatory response in the Gpr101 deficient animals and a reduced Loss of Gpr101 on macrophages disrupted host pro-resolving responses to zymosan challenge with MacGpr101KO

< GPCR News < GPCRs in Oncology and Immunology Prediction of survival and immunotherapy response by the

< GPCR News < GPCRs in Oncology and Immunology Drosophila cytokine GBP2 exerts immune responses and regulates A functional analogue of GBP, stress-responsive peptide (SRP), was also identified in the same species It is expected that the biological responses of two structurally similar peptides should be coordinated Here, we demonstrate that GBP2 replicates the GBP1-mediated cellular immune response from Drosophila Moreover, the GBP2-induced response was silenced by pre-treatment with dsRNA targeting the GBP receptor

Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways Published date October 31, 2023 Abstract performed, and a system pharmacodynamics model (SPD) was developed to capture pancreatic cancer cell responses Here we describe drug effects on pathways associated with cell cycle, DNA damage response (DDR), and

< GPCR News < GPCRs in Oncology and Immunology Spliceosome mutations are associated with clinical response The current study aimed to identify molecular predictors of response to ONV + DAC in R/R AML patients A 10-gene expression signature, predictive of response to ONV + DAC, was derived from the leading-edge The gene signature was not associated with response to DAC alone in an independent dataset. signature to the BeatAML cohort (n = 399), we identified a positive association between predicted ONV + DAC response

protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response protein-coupled receptor class C group 5 member A (GPRC5A) on lipopolysaccharide (LPS)-induced inflammatory response

to CXCL12 but induce different effector responses to regulate cell migration. protein-independent and scavenges CXCL12 to regulate extracellular chemokine levels and maintain CXCR4 responsiveness CXCR4 only responds to wild-type CXCL12 and is sensitive to mutation of the chemokine. By contrast, ACKR3 recruits GPCR kinases (GRKs) and β-arrestins and promiscuously responds to CXCL12, Multiple active-like ACKR3 conformations are populated in response to agonists, compared to the single

signaling in humoral immunity Published date April 4, 2024 Abstract "Efficient induction of humoral immune responses migration of B cells within lymphoid organs, which is governed by G protein-coupled receptors (GPCRs) responding chemoattractant receptors and plays an important role in the control of B cell migration during humoral immune responses

The Leiser laboratory is focused on the molecular mechanisms of aging, with an emphasis on stress response Recent research in his laboratory focuses on how organisms perceive and respond to environmental stress

However, many cancers do not respond to ICB, prompting the search for additional strategies to achieve durable responses. data indicate that Gαs-GPCRs are druggable immune checkpoints that might be targeted to enhance the response

Chinese population Published date September 14, 2023 Abstract "The ability of animals to perceive and respond understanding various sensory modalities, the sense of hygrosensation, which involves the detection and response

was to elucidate the genomic basis of drug resistance or sensitivity, identify signatures for drug response Statistical approaches and machine learning models were applied to identify signatures for drug response Using the mutation pattern for drug response prediction demonstrates high accuracy in predicting sensitivity study highlights the importance of considering the gene mutation patterns for the prediction of drug response

The signaling pathways responsible for LPA/S1P-induced CCN1/2 typically involve activation of the small can potentially play roles in downstream signal transduction events required for LPA and S1P-induced responses activation of additional receptors and signal transduction pathways, contributing to the biphasic delayed responses typically seen in response to growth factors acting via GPCRs.

Abstract "In this current study, we have compared our H3K4me3 Chip-Sequencing data in PC3 cells in response it would be of utmost importance to find out the regions undergoing histone modification changes in response Our study has compared the genes showing H3K4me3 occupancy in response to both TGFβ and IFNγ.

Resting peripheral hM3Dq+PLCβ1 (hM3Dq/β1) T cells did not respond to clozapine, an hM3Dq agonist, unless This permitted large calcium and phosphorylated ERK responses to clozapine.

date April 29, 2024 Abstract "G protein-coupled receptors (GPCRs) regulate many cellular processes in response hormones, neurotransmitters, and odorants, some of which play critical roles in innate and adaptive immune responses demonstrate that GPR141, an orphan GPCR belonging to the class A receptor family, suppresses immune responses These findings suggest that GPR141 functions as a negative regulator of immune responses by controlling

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We also observed PTX-dependent TNT biogenesis in response to lysophosphatidic acid (LPA), indicative of a general response driven by Gi/o-coupled GPCRs. intricate signaling pathways governing the generation of specialized actin-rich elongated structures in response

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Recent evidence indicates that GPR15 may be associated with modulation of the chronic inflammatory response and synovial tissue samples from RA patients, as well as to perform a functional migration assay in response Migration assays were performed using PBMCs isolated from these individuals in response to the synthetic

Overall response and complete response upon salvage therapies were 79% and 39% for talquetamab, 64% and Duration of response, as well as median survival, was significantly improved with bispecific antibodies

program focuses on the molecular and cellular mechanisms regulating G protein-coupled receptor (GPCR) responses , a class of receptors involved in many, if not all, physiological responses, with the ultimate goal

In response to a chemoattractant stimulation, cells lacking PLCγ2 (plcg2kd) displayed altered dynamics of diacylglycerol (DAG) production and calcium response; increased Ras/PI3K/Akt activation; elevated

CCL19 to coordinate collective leukocyte migration Published date September 1, 2023 Abstract "Immune responses (DCs) effectively internalize the receptor and ligand as part of the canonical GPCR desensitization response

His responsibilities include the management of the company’s applications team and providing scientific