Search Results
255 items found for "protein-protein interaction"
- Molecular docking and dynamics simulation studies uncover the host-pathogen protein-protein interactions in Penaeus vannamei and Vibrio parahaemolyticus
interactions in Penaeus vannamei and Vibrio parahaemolyticus Published date January 24, 2024 Abstract Hence, this study was conducted to identify the interaction sites and binding affinity between several Potential interaction sites and the binding affinity between host and pathogen proteins were identified The P. vannamei-V. parahaemolyticus protein-protein interaction of Complex 1 (Ferritin-HrpE/YscL family CheY protein), and Complex 3 (GPCR-Chemotaxis CheY protein) was found to interact with -4319.76, -5271.39
- Ep 128 with Dr. Ilana Kotliar
Ilana uses chemical biology-based methods to study the regulation and protein-protein interactions of GPCRs and a small family of accessory proteins called RAMPs. Ilana’s research is multi-disciplinary and involves a close collaboration with proteomics experts at
- Ep 39 with Dr. Kathryn E Livingston
Product Manager at Gator Bio , a biotechnology company providing solutions to researchers studying protein-protein interactions. researched the beta-2 adrenergic receptor and developed assays to investigate real-time activity in intact
- Stable Binding of Full-Length Chemerin is Driven by Negative Charges in the CMKLR1 N-terminus
This protein ligand plays an important role in obesity and inflammatory processes. Stable receptor-ligand interactions are highly relevant for its different physiological effects, e. g Using receptor chimera of G protein-coupled receptor 1 (GPR1) and CMKLR1, we were able to identify the residues of this interaction and its relevance for stable full-length chemerin binding. Tags double mutant cycle analysis , protein expression , protein-protein interaction , receptor binding
- Illuminating Functional Selectivity and Allosterism at GPCRs.
pharmacology and his research program focuses on the molecular and cellular mechanisms regulating G protein-coupled He has developed innovative methods for in-cellulo measurement of protein-protein interactions, receptor
- Ep 92 with Dr. Stephane Angers
His thesis work led to the development and application of light energy transfer methodology to study protein-protein interaction and signal transduction.
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
C5a is established to interact with a set of genomically related transmembrane receptors, like C5aR1 In addition, the structure of C5aR2 and its interaction specificity toward C5a is not structurally elucidated dynamics data presented in the current study are expected to further enrich the understanding of C5a-C5aR2 interaction Das, Pulkit K Gupta, Soumendra Rana Tags C5a; C5aR2/C5L2 receptor; lipid bilayer; molecular dynamics; protein-protein interactions.
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
< GPCR News < GPCRs in Oncology and Immunology Purinergic GPCR-integrin interactions drive pancreatic pharmacological strategies we demonstrate mechanistically that this ATP-driven invasion requires direct protein-protein interactions between P2Y 2 and αV integrins. Moreover, receptor-integrin interactions were required for effective downstream signalling, leading to This work elucidates a novel GPCR-integrin interaction in cancer invasion, highlighting its potential
- Exploration of prognostic and treatment markers in hepatocellular carcinoma via GPCR-related genes analysis
hepatocellular carcinoma via GPCR-related genes analysis Published date May 15, 2024 Abstract " Background: G protein-coupled Differential expression and functional enrichment analyses were performed; protein-protein interaction
- G protein-coupled estrogen receptor (GPER)/GPR30 forms a complex with the β1-adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells
, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells Published date January 10, 2024 Abstract "G protein-coupled receptor 30 (GPR30), also named G protein-coupled estrogen receptor contain PSD-95/Discs-large/ZO-1 homology (PDZ) motifs in their C-terminal tails through which they interact protein kinase A anchoring protein (AKAP) 5. MCF7 cells through which GPR30 constitutively and PDZ-dependently inhibits β1AR signaling via receptor interaction
- Ep 152 with Dr Arthur Christopoulos
They also discussed the re-emergence of interest in certain programs, the importance of connections across Allosteric Modulation and Drug Discovery Yamina and Arthur delved into the complexities of protein-protein interactions, specifically allosteric modulation. They discussed various modulatory elements, such as RAMPs, G proteins, and GRKs, with Arthur recounting
- TIPE proteins control directed migration of human T cells by directing GPCR and lipid second messenger signaling
The TNF-α-induced protein 8-like (TIPE or TNFAIP8L) family of proteins are newly described pilot proteins T Cells deficient in both of these proteins completely lost their directionality. TNFAIP8 interacted with the Gαi subunit of heterotrimeric (α, β, γ) G-proteins whereas TIPE2 bound to Using deletion and site-directed mutagenesis, we established that Gαi interacted with TNFAIP8 through its C terminal amino acids, and that TIPE2 protein interacted with PIP2 and PIP3 through its positively
- Posters | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
WNT-MB is driven by mutations of the CTNNB1 gene, activating ß-catenin-dependent signaling; however, no interactions MAGI3, a PDZ-containing scaffolding protein is known to downregulate WNT signaling by interacting with interactions using co-IP experiments. We found an interaction between BAI3 and MAGI3 in mouse brain lysates. The y-maze showed a significant sex by genotype interactions with GPR110 KO male mice having increased
- CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions
< GPCR News < GPCRs in Oncology and Immunology CaaX-motif-adjacent residues influence G protein gamma 2023 Abstract "Prenylation is an irreversible post-translational modification that supports membrane interactions optogenetic unmasking-masking of Ct residues was used to probe their contribution to prenylation and membrane interactions of the prenylated proteins. Our findings suggest that specific Ct residues regulate membrane interactions of the Gγ polypeptide,
- Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer
News < GPCRs in Oncology and Immunology Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer Published date April 25, 2023 Abstract " Activation of heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of cell signaling widely However, it has become evident that heterotrimeric G-proteins can also be activated via GPCR-independent Tags G protein , GPCR , cancer , drug discovery .
- G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions
< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions Published date October 1, 2023 Abstract "Human-microorganism interactions play a key role in human health. By combining this with RNA-Seq expression and spatial localization of GPCRs from a public human protein Authors Gajender Aleti , Emily A Troyer , Suzi Hong Tags G protein-coupled receptors , Gut microbiota
- Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
< GPCR News < GPCRs in Oncology and Immunology Intermediate-state-trapped mutants pinpoint G protein-coupled the roles of intermediate states in signaling is pivotal to unraveling the activation processes of G protein-coupled transmembrane helix VI (TM6) and Helix8 that regulates cytoplasmic cavity opening as a "gatekeeper" for G protein thus proposed, allosterically micro-modulated by the cation-π lock and a previously well-defined ionic interaction Intermediate-state-trapped mutants will also provide useful information in relation to receptor-G protein
- Interplay between G protein-coupled receptors and nanotechnology
< GPCR News < GPCRs in Oncology and Immunology Interplay between G protein-coupled receptors and nanotechnology Published date July 28, 2023 Abstract "G protein-coupled receptors (GPCRs), as the largest family of This review aims to summarize the interaction between GPCRs and nanotechnology for understanding their However, there are rare summaries on the interaction between GPCRs and nanoparticles. , Rujing Wang , Mengnan Zhao , Canquan Mao , Sanjun Shi Tags Drug delivery , Endosomal delivery , G protein-coupled
- Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
< GPCR News < GPCRs in Oncology and Immunology Regulator of G protein signaling protein 6 alleviates Regulator of G protein signaling protein 6 (RGS6), identified as a tumor suppressor gene, has received Methods: Congruously regulated G protein-coupled receptor (GPCR)-related genes and differentially expressed Conclusions: RGS6 plays a protective role in ALI not only in early inflammatory responses but also in Tong , Yuanlin Song Tags Acute lung injury , Apoptosis , Cell-renewal , Inflammation , Regulator of G protein
- G Proteins and GPCRs in Cancer: Novel Precision Targeted and Immunotherapies
About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule G Proteins His research team has pioneered the study of G proteins and G protein coupled receptors (GPCRs) in human
- GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer
< GPCR News < GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer Published date March 11, 2023 Abstract " GPR176 belongs to the G protein-coupled receptor superfamily, which responds to external stimuli and Mechanistically, the G protein GNAS is recruited intracellularly to transduce and amplify extracellular
- Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis
Immunology Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling by acting as negative regulators of G proteins. of these mutations on protein function is uncertain. signaling (RGS) proteins.
- G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression
< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression Published date July 31, 2024 Abstract "G protein-coupled receptors (GPCRs) are Additionally, we focus on the roles of GPCRs in regulating immune checkpoint proteins involved in immune
- Agonists of galanin subtype 2 receptor may prevent pancreatic cancer and agonists of angiotensin II type 2 receptor may prevent colorectal cancer
AT2R is interacting with four tumor suppressor proteins, Src homology phosphatase 1, Src homology phosphatase 2, Promyelocytic Leukemia Zinc Finger protein and Microtuble-Associated Scaffold Protein1, the latter also known as Angiotensin-II type 2 receptor-Interacting Protein. Pathways linked to these tumor suppressor proteins may enhance immune surveillance, prevent carcinogenesis
- G protein-coupled receptors related to autoimmunity in postural orthostatic tachycardia syndrome
< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptors related to autoimmunity in In particular, the association of the disease with several types of anti-G protein-coupled receptor ( Authors Yoko Sunami, Keizo Sugaya, Kazushi Takahashi Tags G protein-coupled receptors , Autoimmunity
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
< GPCR News < GPCRs in Oncology and Immunology Regulator of G protein signaling 16 restrains apoptosis G protein signaling (RGS) protein family modulators play essential role within regulating downstream Our study focused on the expression patterns of RGS proteins in CRC, identifying Regulator of G protein We confirmed the elevated RGS16 protein level in CRC, and found that patients with RGS16-high tumors
- G Protein-coupled Receptor-mediated Membrane Targeting of PLCγ2 is Essential for Neutrophil Chemotaxis
< GPCR News < GPCRs in Oncology and Immunology G Protein-coupled Receptor-mediated Membrane Targeting Neutrophil Chemotaxis Published date April 11, 2023 Abstract " The current dogma is that chemoattractants G protein-coupled Tags G protein-coupled receptor (GPCR) , calcium-promoted Ras inactivator (CAPRI) , chemotaxis , neutrophils
- Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors
GPCR News < GPCRs in Oncology and Immunology Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors Published date December 1, 2022 Abstract G Protein-coupled receptors (GPCRs) are the most While the location of the mutations across the protein domains did not differ significantly in the two